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Details on Person TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine

Class:IdReaction:5221014
_displayNameTET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine
_doReleaseTRUE
_timestamp2024-04-12 14:18:10
authored[InstanceEdit:5220992] May, B, 2013-12-28
catalystActivity[CatalystActivity:5220953] DNA 5-methylcytosine dioxygenase activity of TET1,2,3 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5221003] May, B, 2013-12-30
edited[InstanceEdit:5220992] May, B, 2013-12-28
goBiologicalProcess[GO_BiologicalProcess:9907540] chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
inferredFrom
input[OtherEntity:212172] DNA containing 5-mC [nucleoplasm]
[SimpleEntity:113685] O2 [nucleoplasm]
[SimpleEntity:113671] 2OG [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:5220939] Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
[LiteratureReference:5220947] Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
[LiteratureReference:5220998] Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
[LiteratureReference:5221096] Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine
[LiteratureReference:5223019] Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
[LiteratureReference:5220909] Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
[LiteratureReference:5250664] Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis
[LiteratureReference:5250671] Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
[LiteratureReference:5251233] Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
modified[InstanceEdit:5221120] May, B, 2014-01-01
[InstanceEdit:5223048] May, B, 2014-01-03
[InstanceEdit:5250677] May, B, 2014-01-29
[InstanceEdit:5251238] May, B, 2014-02-01
[InstanceEdit:5333792] May, B, 2014-02-21
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9821924] D'Eustachio, Peter, 2022-12-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907541] D'Eustachio, Peter, 2024-04-12
nameTET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine
output[OtherEntity:5221008] DNA containing 5-hmC [nucleoplasm]
[SimpleEntity:159942] CO2 [nucleoplasm]
[SimpleEntity:159939] SUCCA [nucleoplasm]
regulatedBy[PositiveRegulation:5251223] Positive regulation by 'AscH- [nucleoplasm]'
regulationReference[RegulationReference:9641595] Positive regulation by 'AscH- [nucleoplasm]' Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
releaseDate2014-03-12
reviewed[InstanceEdit:5250662] Pfeifer, Gerd P, 2014-01-29
[InstanceEdit:5333791] Mukherji, Mridul, 2014-02-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644529] R-HSA-5221014.6
summation[Summation:5221102] TET1, TET2, and TET3 each oxidize the 5-methyl group of 5-me...
(hasEvent)[Pathway:5221030] TET1,2,3 and TDG demethylate DNA [Homo sapiens]
(precedingEvent)[Reaction:5220990] TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine [Homo sapiens]
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