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Details on Person TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine

Class:IdReaction:5220952
_displayNameTET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine
_doReleaseTRUE
_timestamp2024-04-12 14:18:08
authored[InstanceEdit:5220992] May, B, 2013-12-28
catalystActivity[CatalystActivity:5220953] DNA 5-methylcytosine dioxygenase activity of TET1,2,3 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:5221003] May, B, 2013-12-30
edited[InstanceEdit:5220992] May, B, 2013-12-28
goBiologicalProcess[GO_BiologicalProcess:9907540] chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
inferredFrom
input[OtherEntity:5221062] DNA containing 5-fC [nucleoplasm]
[SimpleEntity:113671] 2OG [nucleoplasm]
[SimpleEntity:113685] O2 [nucleoplasm]
isChimericFALSE
modified[InstanceEdit:5221120] May, B, 2014-01-01
[InstanceEdit:5250677] May, B, 2014-01-29
[InstanceEdit:5333792] May, B, 2014-02-21
[InstanceEdit:9821924] D'Eustachio, Peter, 2022-12-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907541] D'Eustachio, Peter, 2024-04-12
nameTET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine
output[OtherEntity:5220996] DNA containing 5-caC [nucleoplasm]
[SimpleEntity:159942] CO2 [nucleoplasm]
[SimpleEntity:159939] SUCCA [nucleoplasm]
precedingEvent
releaseDate2014-03-12
reviewed[InstanceEdit:5250662] Pfeifer, Gerd P, 2014-01-29
[InstanceEdit:5333791] Mukherji, Mridul, 2014-02-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644571] R-HSA-5220952.4
summation[Summation:5221106] As inferred from mouse, TET1, TET2, and TET3 each oxidize 5-...
(hasEvent)[Pathway:5221030] TET1,2,3 and TDG demethylate DNA [Homo sapiens]
(precedingEvent)[Reaction:5221061] TDG excises 5-carboxylcytosine [Homo sapiens]
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