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Details on Person UniProt:Q9NPB9 ACKR4
| Class:Id | ReferenceGeneProduct:52200 |
|---|---|
| _chainChangeLog | chain:1-350 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NPB9 ACKR4 |
| _timestamp | 2024-11-03 20:08:43 |
| chain | chain:1-350 |
| checksum | 8E26049D2D5757C8 |
| comment | FUNCTION Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.SUBUNIT Forms heteromers with CXCR3. Interacts with ARRB1 and ARRB2.SUBCELLULAR LOCATION Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.TISSUE SPECIFICITY Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.PTM The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily. |
| description | recommendedName: Atypical chemokine receptor 4 alternativeName: C-C chemokine receptor type 11 shortName: C-C CKR-11 shortName: CC-CKR-11 shortName: CCR-11 alternativeName: CC chemokine receptor-like 1 shortName: CCRL1 alternativeName: CCX CKR |
| geneName | ACKR4 CCBP2 CCR11 CCRL1 VSHK1 |
| identifier | Q9NPB9 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Disulfide bond Endosome G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ACKR4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001002] ENSEMBL:ENSG00000129048 ACKR4 [Homo sapiens] |
| secondaryIdentifier | ACKR4_HUMAN B2R9U7 |
| sequenceLength | 350 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:373331] CCRL1 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NPB9 ACKR4 (52200)
