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Details on Person PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)

Class:Id	Reaction:5218952
_displayName	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)
_doRelease	TRUE
_timestamp	2015-03-04 03:58:51
authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:5225659] protein-arginine N-methyltransferase activity of PRMT5:pT5-WDR77, PRMT7 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5218943] Jupe, S, 2013-12-20
edited	[InstanceEdit:3215411] Jupe, S, 2013-03-15
input	[CandidateSet:4657030] Histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:5218932] Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance
modified	[InstanceEdit:5225678] Jupe, S, 2014-01-08 [InstanceEdit:5244790] Jupe, S, 2014-01-21 [InstanceEdit:5246548] Jupe, S, 2014-01-22 [InstanceEdit:5423532] Jupe, Steve, 2014-05-09 [InstanceEdit:5612461] Jupe, Steve, 2014-07-23 [InstanceEdit:5674563] Jupe, Steve, 2015-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3
output	[CandidateSet:5218942] Me2sR3-histone H3 [nucleoplasm] [Homo sapiens] [SimpleEntity:77502] AdoHcy [nucleoplasm]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5423560] Guccione, Ernesto, 2014-05-09 [InstanceEdit:5612458] Fischle, Wolfgang, 2014-07-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644863] R-HSA-5218952.2
summation	[Summation:5218944] Histone H3 is symmetrically dimethylated on arginine-3 by PR...
(hasEvent)	[Pathway:3214858] RMTs methylate histone arginines [Homo sapiens]
(precedingEvent)	[Reaction:5225602] WDR5 binds Me2sR3-replicative histone H3 [Homo sapiens]
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No pathways have been reviewed or authored by PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (5218952)