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Details on Person RIPK3 phosphorylates MLKL

Class:IdReaction:5218906
_displayNameRIPK3 phosphorylates MLKL
_doReleaseTRUE
_timestamp2020-08-30 11:57:04
authored[InstanceEdit:5218858] Shamovsky, V, 2013-12-20
catalystActivity[CatalystActivity:5218886] protein serine/threonine kinase activity of (RIPK1:RIPK3)oligomer:4xMLKL [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:5218889] Shamovsky, V, 2013-12-20
edited[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
input[Complex:5218909] (RIPK1:RIPK3)oligomer:4xMLKL [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:5218888] Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
[LiteratureReference:5620989] Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3
modified[InstanceEdit:5357973] Shamovsky, V, 2014-03-26
[InstanceEdit:5620993] Shamovsky, V, 2014-08-28
[InstanceEdit:5626941] Shamovsky, V, 2014-10-14
[InstanceEdit:5627592] Shamovsky, V, 2014-10-20
[InstanceEdit:5632358] Jassal, Bijay, 2014-10-28
[InstanceEdit:5634117] Jassal, Bijay, 2014-11-03
[InstanceEdit:5635460] Shamovsky, V, 2014-11-07
[InstanceEdit:5643754] Shamovsky, Veronica, 2014-11-17
[InstanceEdit:5675038] Shamovsky, V, 2015-02-15
[InstanceEdit:5675060] Shamovsky, V, 2015-02-15
[InstanceEdit:9686457] Shamovsky, Veronica, 2020-05-01
[InstanceEdit:9693949] Shamovsky, Veronica, 2020-07-08
[InstanceEdit:9697382] Shamovsky, Veronica, 2020-08-14
[InstanceEdit:9697457] Shamovsky, Veronica, 2020-08-17
[InstanceEdit:9698304] Shamovsky, Veronica, 2020-08-25
[InstanceEdit:9698854] Shamovsky, Veronica, 2020-08-30
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRIPK3 phosphorylates MLKL
output[Complex:5218902] (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2015-03-19
reviewed[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
[InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15
[InstanceEdit:9698846] Murphy, James M, 2020-08-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5679793] R-HSA-5218906.4
summation[Summation:5357947] Receptor-interacting serine/threonine-protein kinase 3 (RIPK...
systematicNamep-S-RIPK1:p-S199,227-RIPK3 oligomer phosphorylates 3xMLKL to p-S-RIPK1:p-S199,227-RIPK3 oligomer:3xp-T357,S358-MLKL
(hasEvent)[Pathway:5213460] RIPK1-mediated regulated necrosis [Homo sapiens]
(precedingEvent)[Polymerisation:5357927] MLKL oligomerizes [Homo sapiens]
[Reaction:5364104] RIPK1:RIPK3:MLKL binds PGAM5L [Homo sapiens]
[Reaction:9793451] MLKL binds ITCH [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776804] Update Tracker - [Reaction:5218906] RIPK3 phosphorylates MLKL - v74:[modifyText]
[_UpdateTracker:9776924] Update Tracker - [Reaction:5218906] RIPK3 phosphorylates MLKL - v73:[modifyText]
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