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Details on Person NADPH oxidase 2 generates superoxide from oxygen

Class:Id	Reaction:5218841
_displayName	NADPH oxidase 2 generates superoxide from oxygen
_doRelease	TRUE
_timestamp	2018-11-07 05:18:25
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:5218817] superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC1:GTP [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5218840] Garapati, P V, 2013-12-19
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30 [InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02 [InstanceEdit:9626901] Shamovsky, Veronica, 2018-10-29
input	[SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:352327] O2 [extracellular region] [SimpleEntity:352327] O2 [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:5218352] The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology
modified	[InstanceEdit:5228988] Garapati, P V, 2014-01-15 [InstanceEdit:5432676] Garapati, P V, 2014-05-12 [InstanceEdit:5490368] Garapati, P V, 2014-05-19 [InstanceEdit:5674562] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9628189] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9628203] Shamovsky, Veronica, 2018-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NADPH oxidase 2 generates superoxide from oxygen
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:3299686] O2.- [extracellular region] [SimpleEntity:3299686] O2.- [extracellular region]
precedingEvent	[Reaction:5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 [Homo sapiens] [Reaction:5218850] VAV exchanges GTP for GDP on RAC1, activating it [Homo sapiens] [Reaction:5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644533] R-HSA-5218841.3
summation	[Summation:5218479] The activated NOX2 complex generates superoxide (O2.-) by tr...
(hasEvent)	[Pathway:4420097] VEGFA-VEGFR2 Pathway [Homo sapiens] [Pathway:5668599] RHO GTPases Activate NADPH Oxidases [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778965] Update Tracker - [Reaction:5218841] NADPH oxidase 2 generates superoxide from oxygen - v67:[add_removeInput, add_removeOutput]
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No pathways have been reviewed or authored by NADPH oxidase 2 generates superoxide from oxygen (5218841)