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Details on Person DOCK180:ELMO exchanges GTP for GDP, activating RAC1

Class:IdReaction:5218839
_displayNameDOCK180:ELMO exchanges GTP for GDP, activating RAC1
_doReleaseTRUE
_timestamp2016-03-04 13:55:08
authored[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity[CatalystActivity:5218831] guanyl-nucleotide exchange factor activity of CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643413] guanyl-nucleotide exchange factor activity of CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:5218840] Garapati, P V, 2013-12-19
edited[InstanceEdit:4420157] Garapati, P V, 2013-08-30
input[SimpleEntity:29438] GTP [cytosol]
[Complex:5674631] RAC1:GDP [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:372673] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
modified[InstanceEdit:5432676] Garapati, P V, 2014-05-12
[InstanceEdit:5490368] Garapati, P V, 2014-05-19
[InstanceEdit:8863086] Garapati, Phani Vijay, 2016-03-04
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDOCK180:ELMO exchanges GTP for GDP, activating RAC1
output[SimpleEntity:29420] GDP [cytosol]
[Complex:442641] RAC1:GTP [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2014-06-10
reviewed[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5645131] R-HSA-5218839.4
summation[Summation:5218492] RAC1 is activated from inactive GDP-bound state to active GT...
(hasEvent)[Pathway:4420097] VEGFA-VEGFR2 Pathway [Homo sapiens]
(precedingEvent)[Reaction:2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) [Homo sapiens]
[Reaction:5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783126] Update Tracker - [Reaction:5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - v57:[add_removeInput, add_removeOutput]
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