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Details on Person p-6Y-VEGFR2 binds NCK

Class:Id	Reaction:5218815
_displayName	p-6Y-VEGFR2 binds NCK
_doRelease	TRUE
_timestamp	2024-03-20 23:21:45
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5218840] Garapati, P V, 2013-12-19
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
input	[DefinedSet:381949] NCK1,NCK2 [cytosol] [Homo sapiens] [Complex:4420101] VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5218587] Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
modified	[InstanceEdit:5432676] Garapati, P V, 2014-05-12 [InstanceEdit:5490368] Garapati, P V, 2014-05-19 [InstanceEdit:9026722] Rothfels, Karen, 2017-10-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9866007] Orlic-Milacic, Marija, 2024-03-20
name	p-6Y-VEGFR2 binds NCK
negativePrecedingEvent	[NegativePrecedingEvent:9866003] Futile Cycle: PLCG1 disassociates from VEGFR2 and translocate to PM
output	[Complex:5218798] VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:4420117] VEGFR2 autophosphorylates [Homo sapiens] [Reaction:194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization [Homo sapiens] [Reaction:9691215] VEGFA-165 dimer binds VEGFR2 dimer [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644478] R-HSA-5218815.4
summation	[Summation:5218581] In response to VEGF, the increased actin polymerization requ...
(hasEvent)	[Pathway:4420097] VEGFA-VEGFR2 Pathway [Homo sapiens]
(precedingEvent)	[Reaction:5218824] p-6Y-VEGFR2 binds FYN [Homo sapiens]
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No pathways have been reviewed or authored by p-6Y-VEGFR2 binds NCK (5218815)