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Details on Person PI3-kinase (PI3K) catalyzes the phosphorylation of inositol ...

Class:IdSummation:5218570
_displayNamePI3-kinase (PI3K) catalyzes the phosphorylation of inositol ...
_timestamp2014-01-10 16:33:14
created[InstanceEdit:5218480] Garapati, P V, 2013-12-19
literatureReference[LiteratureReference:389304] Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
[LiteratureReference:5218543] VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2
modified[InstanceEdit:5228340] Jupe, S, 2014-01-10
textPI3-kinase (PI3K) catalyzes the phosphorylation of inositol phospholipids at the 3 position to generate phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate. PIP2 and PIP3 generated serve as lipid substrates where they recruit guanine nucleotide exchange factors (GEFs) like VAV (Proto-oncogene vav) that catalyze the exchange of GDP for GTP on Rac, activating it (Han et al. 1998). VAV2 acts downstream of VEGF to activate Rac1 (Garretta et al. 2007).
(summation)[Reaction:5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
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