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Details on Person Tyrosine-phosphorylated VAVs act as guanine nucleotide excha...
| Class:Id | Summation:5218482 |
|---|---|
| _displayName | Tyrosine-phosphorylated VAVs act as guanine nucleotide excha... |
| _timestamp | 2024-02-21 23:00:02 |
| created | [InstanceEdit:5218480] Garapati, P V, 2013-12-19 |
| literatureReference | [LiteratureReference:5218582] VEGF signaling through NADPH oxidase-derived ROS [LiteratureReference:5229173] Regulation of leading edge microtubule and actin dynamics downstream of Rac1 [LiteratureReference:9861981] Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent |
| modified | [InstanceEdit:5228340] Jupe, S, 2014-01-10 [InstanceEdit:5229176] Garapati, P V, 2014-01-16 [InstanceEdit:9828803] Orlic-Milacic, Marija, 2023-02-17 [InstanceEdit:9861984] Orlic-Milacic, Marija, 2024-02-21 |
| text | Tyrosine-phosphorylated VAVs act as guanine nucleotide exchange factors (GEFs) for RAC1, catalysing the exchange of bound GDP for GTP. RAC1 is a key regulator for actin cytoskeleton and cell migration and is also a critical component of endothelial NADPH oxidase (Wittmann et al. 2003, Tan et al. 2008, Ushio–Fukai 2007, Pricei et al. 2002). Activated RAC1 then stimulates actin polymerization to form lamellipodia through a number of proteins such as WASP-family veroprilin homologous protein (WAV). WAVE proteins stimulate the formation of a branched actin network by binding to the p21 subunit of the ARP2/3 nucleating complex, which is located on the sides of the pre-existing filaments. |
| (summation) | [Reaction:5218850] VAV exchanges GTP for GDP on RAC1, activating it [Homo sapiens] |
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