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Details on Person PRMT5 can methylate histone H2A at arginine-4 (H2AR3) (Pal e...

Class:Id	Summation:5218321
_displayName	PRMT5 can methylate histone H2A at arginine-4 (H2AR3) (Pal e...
_timestamp	2014-07-21 12:33:26
created	[InstanceEdit:5218320] Jupe, S, 2013-12-18
literatureReference	[LiteratureReference:3215351] Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes [LiteratureReference:5212680] The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
modified	[InstanceEdit:5610084] Jupe, Steve, 2014-07-21
text	PRMT5 can methylate histone H2A at arginine-4 (H2AR3) (Pal et al. 2004). The histone-binding protein cooperator of PRMT5 (COPRS) guides PRMT5:WDR77 to methylate histone H4 arginine-4 (H4R3) rather than histone H3 arginine-9 (H3R8) (Lacroix et al. 2008) and may also be responsible for guiding PRMT5:WDR77 to methylate histone H2A arginine-4 (H2AR3).
(summation)	[BlackBoxEvent:5216234] PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) [Homo sapiens]
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