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Details on Person Anthrax lef cleaves target cell MAP2K1 (MEK1)

Class:Id	Reaction:5211340
_displayName	Anthrax lef cleaves target cell MAP2K1 (MEK1)
_doRelease	TRUE
_timestamp	2021-08-13 19:33:20
authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
catalystActivity	[CatalystActivity:5211347] metallopeptidase activity of lef [cytosol]
catalystActivityReference	[CatalystActivityReference:9643065] metallopeptidase activity of LF [cytosol] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5211335] D'Eustachio, Peter, 2013-12-09
disease	[Disease:5205706] anthrax disease
input	[EntityWithAccessionedSequence:59502] MAP2K1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5211331] Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor [LiteratureReference:5211333] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity [LiteratureReference:5211349] Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
modified	[InstanceEdit:5211358] D'Eustachio, Peter, 2013-12-09 [InstanceEdit:5212688] D'Eustachio, Peter, 2013-12-12 [InstanceEdit:5212698] D'Eustachio, Peter, 2013-12-13 [InstanceEdit:5212702] D'Eustachio, Peter, 2013-12-13 [InstanceEdit:5228341] D'Eustachio, Peter, 2014-01-10 [InstanceEdit:5365821] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5490365] D'Eustachio, Peter, 2014-05-19 [InstanceEdit:5567363] D'Eustachio, Peter, 2014-05-23 [InstanceEdit:5576993] Matthews, Lisa, 2014-05-28 [InstanceEdit:5663288] D'Eustachio, Peter, 2015-01-17 [InstanceEdit:5665756] D'Eustachio, Peter, 2015-01-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9750516] D'Eustachio, Peter, 2021-08-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Anthrax lef cleaves target cell MAP2K1 (MEK1)
output	[EntityWithAccessionedSequence:5211342] MAP2K1(2-8) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5211353] MAP2K1(9-393) [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5210947] pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) [Homo sapiens] [BlackBoxEvent:5210944] Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) [Homo sapiens] [BlackBoxEvent:5210943] pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) [Homo sapiens] [BlackBoxEvent:5210959] Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) [Homo sapiens]
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645085] R-HSA-5211340.6
summation	[Summation:5211355] lef (Anthrax LF, lethal factor), a zinc metalloprotease (Kli...
(hasEvent)	[Pathway:5210891] Uptake and function of anthrax toxins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776580] Update Tracker - [Reaction:5211340] Anthrax lef cleaves target cell MAP2K1 (MEK1) - v75:[modifyText]
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No pathways have been reviewed or authored by Anthrax lef cleaves target cell MAP2K1 (MEK1) (5211340)