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Details on Person Sirt1 [nucleoplasm]

Class:Id	EntityWithAccessionedSequence:5211238
_displayName	Sirt1 [nucleoplasm]
_timestamp	2014-11-20 03:07:19
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5211237] May, B, 2013-12-09
endCoordinate	737
name	Sirt1 NAD-dependent protein deacetylase sirtuin-1 ecNumber3.5.1.-/ecNumber SIR1_MOUSE
referenceEntity	[ReferenceGeneProduct:101615] UniProt:Q923E4 Sirt1 [Mus musculus]
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:5645599] R-MMU-5211238.1
startCoordinate	2
(activeUnit)	[CatalystActivity:9859851] NAD-dependent protein lysine deacetylase activity of Sirt1:Ac-K544,p-Bmal1:p-Clock,p-Npas2:Dbp gene [nucleoplasm] [CatalystActivity:9960049] NAD-dependent protein lysine deacetylase activity of Ac-13K-Ppargc1a:Sirt1:Rora:Bmal1 gene [nucleoplasm]
(hasComponent)	[Complex:9859891] Sirt1:p-Bmal1:p-Clock,p-Npas2:Dbp gene [nucleoplasm] [Mus musculus] [Complex:9859940] Sirt1:Ac-K544,p-Bmal1:p-Clock,p-Npas2:Nampt gene [nucleoplasm] [Mus musculus] [Complex:9860207] Sirt1:Ac-K544,p-Bmal1:Clock:Per2 gene [nucleoplasm] [Mus musculus] [Complex:9860208] Sirt1:p-Bmal1:p-Clock:Per2 gene [Mus musculus] [Complex:9960051] Ac-13K-Ppargc1a:Sirt1:Rora:Bmal1 gene [nucleoplasm] [Mus musculus] [Complex:9960079] Ppargc1a:Sirt1:Rora:Bmal1 gene [nucleoplasm] [Mus musculus] [Complex:9983371] Sirt1:Ac-K544,p-Bmal1:p-Clock,p-Npas2:Dbp gene [nucleoplasm] [Mus musculus]
(input)	[Reaction:9859951] Sirt1 binds Ac-K544,p-Bmal1:p-Clock,p-Npas2:Nampt gene [Mus musculus] [Reaction:9860216] Sirt1 binds Ac-K544,p-Bmal1:Clock:Per2 gene [Mus musculus] [Reaction:9982776] Sirt1 binds Ac-13K-Ppargc1a:Rora:Bmal1 [Mus musculus]
(output)	[BlackBoxEvent:9958955] p-S97-Bmal1:p-T451,T461-Clock positively regulates expression of Sirt1 [Mus musculus]
(physicalEntity)	[CatalystActivity:5211242] NAD-dependent protein lysine deacetylase activity of Sirt1 [nucleoplasm]
(regulator)	[PositiveGeneExpressionRegulation:9931507] Positive gene expression regulation by 'Sirt1 [nucleoplasm]'
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No pathways have been reviewed or authored by Sirt1 [nucleoplasm] (5211238)