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Details on Person Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)

Class:Id	BlackBoxEvent:5210944
_displayName	Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)
_doRelease	TRUE
_timestamp	2020-10-08 22:00:01
authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
compartment	[Compartment:876] plasma membrane [Compartment:74700] endosome membrane
created	[InstanceEdit:5210945] D'Eustachio, Peter, 2013-12-07
disease	[Disease:5205706] anthrax disease
input	[Complex:5210915] cya:lef:(pagA(197-794):ANTXR1 oligomer) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5487064] Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process [LiteratureReference:5212278] EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin [LiteratureReference:5487077] Receptors of anthrax toxin and cell entry
modified	[InstanceEdit:5210960] D'Eustachio, Peter, 2013-12-07 [InstanceEdit:5212280] D'Eustachio, Peter, 2013-12-11 [InstanceEdit:5212698] D'Eustachio, Peter, 2013-12-13 [InstanceEdit:5213077] D'Eustachio, Peter, 2013-12-13 [InstanceEdit:5228341] D'Eustachio, Peter, 2014-01-10 [InstanceEdit:5365821] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5488242] D'Eustachio, Peter, 2014-05-17 [InstanceEdit:5490365] D'Eustachio, Peter, 2014-05-19 [InstanceEdit:5567363] D'Eustachio, Peter, 2014-05-23 [InstanceEdit:5576993] Matthews, Lisa, 2014-05-28 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)
output	[Complex:5210940] cya:lef:(pagA(197-794):ANTXR1 oligomer) [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:5210923] cya and lef bind to pagA(197-794):ANTXR1 oligomer [Homo sapiens] [Reaction:5210909] ANTXR1-bound pagA(197-794) forms oligomers [Homo sapiens]
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644927] R-HSA-5210944.4
summation	[Summation:5210948] cya (Anthrax EF, edema factor) and lef (LF, lethal factor) t...
(hasEvent)	[Pathway:5210891] Uptake and function of anthrax toxins [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:5210947] pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776541] Update Tracker - [BlackBoxEvent:5210944] Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) - v75:[modifyText]
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