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Details on Person ANTXR1-bound pagA(197-794) forms oligomers

Class:Id	Reaction:5210909
_displayName	ANTXR1-bound pagA(197-794) forms oligomers
_doRelease	TRUE
_timestamp	2020-10-08 21:59:50
authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5210902] D'Eustachio, Peter, 2013-12-07
disease	[Disease:5205706] anthrax disease
input	[Complex:5210006] pagA(197-794):ANTXR1 [plasma membrane] [Homo sapiens] [Complex:5210006] pagA(197-794):ANTXR1 [plasma membrane] [Homo sapiens] [Complex:5210006] pagA(197-794):ANTXR1 [plasma membrane] [Homo sapiens] [Complex:5210006] pagA(197-794):ANTXR1 [plasma membrane] [Homo sapiens] [Complex:5210006] pagA(197-794):ANTXR1 [plasma membrane] [Homo sapiens] [Complex:5210006] pagA(197-794):ANTXR1 [plasma membrane] [Homo sapiens] [Complex:5210006] pagA(197-794):ANTXR1 [plasma membrane] [Homo sapiens] [Complex:5210006] pagA(197-794):ANTXR1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5487056] The protective antigen component of anthrax toxin forms functional octameric complexes [LiteratureReference:5487071] Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma [LiteratureReference:5210899] Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation [LiteratureReference:5209992] Crystal structure of a complex between anthrax toxin and its host cell receptor [LiteratureReference:5210920] Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen [LiteratureReference:5205699] Anthrax toxin: receptor binding, internalization, pore formation, and translocation
modified	[InstanceEdit:5212698] D'Eustachio, Peter, 2013-12-13 [InstanceEdit:5213077] D'Eustachio, Peter, 2013-12-13 [InstanceEdit:5228341] D'Eustachio, Peter, 2014-01-10 [InstanceEdit:5365821] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5488242] D'Eustachio, Peter, 2014-05-17 [InstanceEdit:5490365] D'Eustachio, Peter, 2014-05-19 [InstanceEdit:5567363] D'Eustachio, Peter, 2014-05-23 [InstanceEdit:5576993] Matthews, Lisa, 2014-05-28 [InstanceEdit:5663288] D'Eustachio, Peter, 2015-01-17 [InstanceEdit:5665756] D'Eustachio, Peter, 2015-01-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ANTXR1-bound pagA(197-794) forms oligomers
output	[Complex:5210928] pagA(197-794):ANTXR1 oligomer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:5210935] Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) [Homo sapiens] [Reaction:5210921] pagA binds ANTXR1 [Homo sapiens]
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644801] R-HSA-5210909.4
summation	[Summation:5210907] ANTXR1 (Anthrax Receptor 1)-bound pagA(197-794) (protective ...
(hasEvent)	[Pathway:5210891] Uptake and function of anthrax toxins [Homo sapiens]
(precedingEvent)	[Reaction:5210923] cya and lef bind to pagA(197-794):ANTXR1 oligomer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776646] Update Tracker - [Reaction:5210909] ANTXR1-bound pagA(197-794) forms oligomers - v75:[modifyText]
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