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Details on Person Extracellular pagA (PA83, full length Protective Antigen - P...
| Class:Id | Summation:5210890 |
|---|---|
| _displayName | Extracellular pagA (PA83, full length Protective Antigen - P... |
| _timestamp | 2020-10-08 22:00:02 |
| created | [InstanceEdit:5210902] D'Eustachio, Peter, 2013-12-07 |
| modified | [InstanceEdit:5212688] D'Eustachio, Peter, 2013-12-12 [InstanceEdit:5213077] D'Eustachio, Peter, 2013-12-13 [InstanceEdit:5216624] D'Eustachio, Peter, 2013-12-16 [InstanceEdit:5490365] D'Eustachio, Peter, 2014-05-19 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 |
| text | Extracellular pagA (PA83, full length Protective Antigen - Petosa et al. 1997) produced by Bacillus anthracis binds to either of two isoforms of ANTXR2 (Anthrax Toxin Receptor 2, also known as CMG2 - Scobie et al. 2003) in the plasma membrane of a target human cell. The physiological ligand for ANTXR2 is not known, but this receptor has been shown to be the primary receptor involved in anthrax toxin pathogenesis (Liu et al. 2009). While some studies suggest that ANTXR2 is associated with palmitoylated LRP6 (low density lipoprotein receptor related protein 6 - Abrami et al. 2008) in the plasma membrane and that the latter protein can function as a co-receptor (Wei et al. 2006), the role of LRP6 in PA83 uptake remains uncertain (reviewed by van der Goot & Young 2009) and no function for LRP6 is annotated here. |
| (summation) | [Reaction:5210918] pagA binds ANTXR2 [Homo sapiens] |
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No pathways have been reviewed or authored by Extracellular pagA (PA83, full length Protective Antigen - P... (5210890)
