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Details on Person UniProt:O43734 TRAF3IP2
| Class:Id | ReferenceGeneProduct:52096 |
|---|---|
| _chainChangeLog | chain:1-574 added on Fri February 6 2015 |
| _displayName | UniProt:O43734 TRAF3IP2 |
| _timestamp | 2024-11-03 20:18:23 |
| chain | chain:1-574 |
| checksum | 4985795466D71422 |
| comment | FUNCTION E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SUBUNIT Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta (PubMed:12459498). Interacts with TRAF6; this interaction is direct (PubMed:12459498, PubMed:19825828). Interacts with IL17RA and IL17RC (PubMed:19825828, PubMed:24120361, PubMed:33723527). Interacts with IL17RB (PubMed:24120361).INTERACTION Widely expressed.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.CAUTION The presence of U-box domain is not predicted by SMART and SWISS-MODEL tools.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: fullName evidence="18"E3 ubiquitin ligase TRAF3IP2 ecNumber evidence="8"2.3.2.27 alternativeName: Adapter protein CIKS alternativeName: Connection to IKK and SAPK/JNK alternativeName: E3 ubiquitin-protein ligase CIKS alternativeName: Nuclear factor NF-kappa-B activator 1 shortName: ACT1 alternativeName: TRAF3-interacting protein 2 |
| geneName | TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6 |
| identifier | O43734 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Disease variant Inflammatory response Proteomics identification Reference proteome Transferase Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TRAF3IP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003443] ENSEMBL:ENSG00000056972 TRAF3IP2 [Homo sapiens] |
| secondaryIdentifier | CIKS_HUMAN B2RAY9 E1P555 Q5R3A3 Q7Z6Q1 Q7Z6Q2 Q7Z6Q3 Q9H5W2 Q9H6Y3 Q9NS14 Q9UG72 |
| sequenceLength | 574 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145432] UniProt:O43734-2 TRAF3IP2 [Homo sapiens] [ReferenceIsoform:384721] UniProt:O43734-3 TRAF3IP2 [Homo sapiens] [ReferenceIsoform:401556] UniProt:O43734-1 TRAF3IP2 [Homo sapiens] [ReferenceIsoform:8966013] UniProt:O43734-4 TRAF3IP2 [Homo sapiens] [ReferenceIsoform:8966014] UniProt:O43734-5 TRAF3IP2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8979712] TRAF3IP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8979788] p-S162,S220,S-TRAF3IP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8980429] K48polyUb,p-S162,S220,S-TRAF3IP2 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8979790] O-phospho-L-serine at 162 [ModifiedResidue:8979792] O-phospho-L-serine at 220 [ModifiedResidue:8979793] O-phospho-L-serine at unknown position |
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No pathways have been reviewed or authored by UniProt:O43734 TRAF3IP2 (52096)
