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Details on Person UniProt:Q9UHD4 CIDEB
| Class:Id | ReferenceGeneProduct:52080 |
|---|---|
| _chainChangeLog | chain:1-219 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UHD4 CIDEB |
| _timestamp | 2024-11-03 20:13:43 |
| chain | chain:1-219 |
| checksum | E0B4E5EF1F7C912D |
| comment | FUNCTION Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:35939579). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:35939579). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (By similarity). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (By similarity). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (By similarity). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (By similarity). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (By similarity). May also activate apoptosis (PubMed:10619428).FUNCTION (Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes.SUBUNIT Interacts with DFFA (PubMed:10619428). Interacts with DFFB; inhibited by DFFB (PubMed:10619428). Interacts with APOB. Interacts with PREB/SEC12; facilitating loading of SCAP-SREBP into COPII vesicles (By similarity).SUBUNIT (Microbial infection) Interacts (via N-terminus) with HCV non-structural protein 5A (via N-terminus); this interaction seems to regulate the association of HCV particles with ApoE.INTERACTION Enriched at lipid droplet contact sites.TISSUE SPECIFICITY Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.SIMILARITY Belongs to the CIDE family. |
| description | recommendedName: fullName evidence="10"Lipid transferase CIDEB alternativeName: fullName evidence="8"Cell death activator CIDE-B alternativeName: fullName evidence="8"Cell death-inducing DFFA-like effector B |
| geneName | CIDEB |
| identifier | Q9UHD4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Apoptosis Cytoplasmic vesicle Endoplasmic reticulum Golgi apparatus Host-virus interaction Lipid droplet Membrane Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CIDEB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994130] ENSEMBL:ENSG00000136305 CIDEB [Homo sapiens] |
| secondaryIdentifier | CIDEB_HUMAN D3DS73 Q546V8 Q9NNW9 |
| sequenceLength | 219 |
| species | [Species:48887] Homo sapiens |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UHD4 CIDEB (52080)
