Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O60543 CIDEA
| Class:Id | ReferenceGeneProduct:52078 |
|---|---|
| _chainChangeLog | chain:1-219 added on Fri February 6 2015 |
| _displayName | UniProt:O60543 CIDEA |
| _timestamp | 2024-11-03 20:13:43 |
| chain | chain:1-219 |
| checksum | 05F704823CE71C0E |
| comment | FUNCTION Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:19843876, PubMed:26118629). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:19843876). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (By similarity). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (By similarity). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (By similarity).CATALYTIC ACTIVITY a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)SUBUNIT Homodimer (PubMed:19843876). Interacts with CIDEC (PubMed:19843876). Directly interacts with CEBPB (By similarity). Interacts with isoform CLSTN3beta of CLSTN3; inhibiting the lipid transferase activity of CIDEA (By similarity).SUBCELLULAR LOCATION Enriched at lipid droplet contact sites.TISSUE SPECIFICITY Expressed in omental and subcutaneous adipose tissue (at protein level).DOMAIN The amphipathic helix mediates embedding into the lipid droplet phospholipid monolayer, promoting phosphatidic acid-binding, thereby facilitating triacylglycerol transfer.DOMAIN The CIDE-N domain is involved in homodimerization which is crucial for its function in promoting lipid exchange and transfer.DISEASE In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle.SIMILARITY Belongs to the CIDE family. |
| description | recommendedName: fullName evidence="10"Lipid transferase CIDEA alternativeName: fullName evidence="9"Cell death activator CIDE-A alternativeName: fullName evidence="10"Cell death-inducing DFFA-like effector A |
| geneName | CIDEA |
| identifier | O60543 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Apoptosis Lipid droplet Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CIDEA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991774] ENSEMBL:ENSG00000176194 CIDEA [Homo sapiens] |
| secondaryIdentifier | CIDEA_HUMAN B0YIY7 Q6UPR7 |
| sequenceLength | 219 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8856626] CIDEA [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60543 CIDEA (52078)
