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Details on Person UniProt:Q9P0U4 CXXC1
| Class:Id | ReferenceGeneProduct:51970 |
|---|---|
| _chainChangeLog | chain:1-656 added on Sat February 7 2015 |
| _displayName | UniProt:Q9P0U4 CXXC1 |
| _timestamp | 2024-11-03 20:09:31 |
| chain | chain:1-656 |
| checksum | 6D2376E449905A18 |
| comment | FUNCTION Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.SUBUNIT Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1 HCFC1 and DPY30. Interacts with SETD1A. Interacts with ZNF335. Interacts with PRDM9; this interaction does not link PRDM9-activated recombination hotspot sites with DSB machinery and is not required for the hotspot recognition pathway. Interacts with histone H3K4me3 (By similarity).INTERACTION Associated with euchromatin. During mitosis, excluded from condensed chromosomes.ALTERNATIVE PRODUCTS Ubiquitous.DOMAIN The acidic domain carries the potential to activate transcription.PTM May be regulated by proteolysis. |
| description | recommendedName: CXXC-type zinc finger protein 1 alternativeName: CpG-binding protein alternativeName: PHD finger and CXXC domain-containing protein 1 |
| geneName | CXXC1 CFP1 CGBP PCCX1 PHF18 |
| identifier | Q9P0U4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Activator Alternative splicing Coiled coil DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CXXC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5642205] ENSEMBL:ENSG00000154832 CXXC1 [Homo sapiens] |
| secondaryIdentifier | CXXC1_HUMAN B2RC03 Q8N2W4 Q96BC8 Q9P2V7 |
| sequenceLength | 656 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973715] UniProt:Q9P0U4-1 CXXC1 [Homo sapiens] [ReferenceIsoform:8973716] UniProt:Q9P0U4-2 CXXC1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:535610] CXXC1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9P0U4 CXXC1 (51970)
