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Details on Person UniProt:Q9Y3B4 SF3B6
| Class:Id | ReferenceGeneProduct:51962 |
|---|---|
| _chainChangeLog | chain:1-125 added on Sat February 7 2015 |
| _displayName | UniProt:Q9Y3B4 SF3B6 |
| _timestamp | 2026-02-20 23:00:15 |
| chain | chain:1-125 |
| checksum | A1439DACB78A3208 |
| comment | FUNCTION Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B6 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). Within the 17S U2 SnRNP complex, SF3B6 directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (PubMed:16432215). SF3B6 stabilizes the intron branch site-U2 snRNA duplex, thereby promoting-binding of introns with poor sequence complementarity (PubMed:34822310). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932).SUBUNIT Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:12234937, PubMed:15146077, PubMed:32494006, PubMed:34822310). Part of the SF3B subcomplex of the 17S U2 SnRNP complex (PubMed:12234937, PubMed:12738865, PubMed:16432215, PubMed:27720643, PubMed:28541300). SF3B associates with the splicing subcomplex SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) (PubMed:12234937). Within the SF3B complex interacts directly with SF3B1 (PubMed:16432215, PubMed:21062891, Ref.20). Component of the minor spliceosome, which splices U12-type introns (PubMed:15146077, PubMed:33509932).SUBCELLULAR LOCATION Belongs to the SF3B6 family. |
| description | recommendedName: Splicing factor 3B subunit 6 alternativeName: Pre-mRNA branch site protein p14 alternativeName: SF3b 14 kDa subunit shortName: SF3B14a alternativeName: Spliceosome-associated protein, 14-kDa alternativeName: Splicing factor 3b, subunit 6, 14kDa |
| geneName | SF3B6 SAP14 SF3B14 SF3B14A CGI-110 HSPC175 HT006 |
| identifier | Q9Y3B4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Isopeptide bond mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome RNA-binding Spliceosome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SF3B6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000841] ENSEMBL:ENSG00000115128 SF3B6 [Homo sapiens] |
| secondaryIdentifier | SF3B6_HUMAN Q53TM1 |
| sequenceLength | 125 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:83808] SF3B6 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y3B4 SF3B6 (51962)
