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Details on Person UniProt:O15519 CFLAR

Class:IdReferenceGeneProduct:51926
_chainChangeLogchain:1-376 added on Fri February 6 2015;chain:377-480 added on Fri February 6 2015
_displayNameUniProt:O15519 CFLAR
_timestamp2026-02-20 22:19:55
chainchain:1-376
chain:377-480
checksum8C6D7E92AE1EB672
commentFUNCTION Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells (PubMed:31046799). Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.SUBUNIT TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and CASP8 (PubMed:9880531). A proteolytic fragment (p43) stays associated with the DISC (PubMed:9880531). Also interacts with FADD, CASP8, CASP3, TRAF1, TRAF2 and Bcl-X(L) (in vitro) (PubMed:9208847, PubMed:9326610). Interacts with RIPK1 (By similarity) (PubMed:9208847, PubMed:9326610, PubMed:9880531). Interacts with GMEB1 (PubMed:31046799).SUBUNIT (Microbial infection) Interacts with HBV protein X.INTERACTION Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.INDUCTION Repressed by IL2/interleukin-2 after TCR stimulation, during progression to the S phase of the cell cycle.DOMAIN The caspase domain lacks the active site residues involved in catalysis.PTM Proteolytically processed by CASP8 generating subunit p43 and p12.PTM Deubiquitinated by USP40, leading to stabilization.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the peptidase C14A family.
descriptionrecommendedName: CASP8 and FADD-like apoptosis regulator alternativeName: Caspase homolog shortName: CASH alternativeName: Caspase-eight-related protein shortName: Casper alternativeName: Caspase-like apoptosis regulatory protein shortName: CLARP alternativeName: Cellular FLICE-like inhibitory protein shortName: c-FLIP alternativeName: FADD-like antiapoptotic molecule 1 shortName: FLAME-1 alternativeName: Inhibitor of FLICE shortName: I-FLICE alternativeName: MACH-related inducer of toxicity shortName: MRIT alternativeName: Usurpin component recommendedName: CASP8 and FADD-like apoptosis regulator subunit p43 /component component recommendedName: CASP8 and FADD-like apoptosis regulator subunit p12 /component
geneNameCFLAR
CASH
CASP8AP1
CLARP
MRIT
identifierO15519
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Apoptosis
Host-virus interaction
Proteomics identification
Reference proteome
Repeat
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
nameCFLAR
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9004598] ENSEMBL:ENSG00000003402 CFLAR [Homo sapiens]
secondaryIdentifierCFLAR_HUMAN
B4DJE0
B7Z9F9
O14673
O14674
O14675
O15137
O15138
O15356
O15510
O43618
O43619
O43620
O60458
O60459
Q53TS6
Q54AF1
Q96TE4
Q9UEW1
sequenceLength480
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:145326] UniProt:O15519-2 CFLAR [Homo sapiens]
[ReferenceIsoform:145327] UniProt:O15519-3 CFLAR [Homo sapiens]
[ReferenceIsoform:145328] UniProt:O15519-4 CFLAR [Homo sapiens]
[ReferenceIsoform:145329] UniProt:O15519-5 CFLAR [Homo sapiens]
[ReferenceIsoform:145330] UniProt:O15519-6 CFLAR [Homo sapiens]
[ReferenceIsoform:145331] UniProt:O15519-7 CFLAR [Homo sapiens]
[ReferenceIsoform:145332] UniProt:O15519-8 CFLAR [Homo sapiens]
[ReferenceIsoform:145333] UniProt:O15519-9 CFLAR [Homo sapiens]
[ReferenceIsoform:145334] UniProt:O15519-10 CFLAR [Homo sapiens]
[ReferenceIsoform:145335] UniProt:O15519-11 CFLAR [Homo sapiens]
List all 15 refering instances
(referenceEntity)[EntityWithAccessionedSequence:51925] CFLAR(1-376) [cytosol] [Homo sapiens]
(referenceSequence)[GroupModifiedResidue:9793989] ubiquitinylated lysine (M1polyUb [cytosol]) at 353
[GroupModifiedResidue:9794011] ubiquitinylated lysine (M1polyUb [cytosol]) at 351
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No pathways have been reviewed or authored by UniProt:O15519 CFLAR (51926)
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