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Details on Person UniProt:Q03188 CENPC
| Class:Id | ReferenceGeneProduct:51888 |
|---|---|
| _chainChangeLog | chain:1-943 added on Fri February 6 2015 |
| _displayName | UniProt:Q03188 CENPC |
| _timestamp | 2024-11-03 19:50:22 |
| chain | chain:1-943 |
| checksum | 2AA5AF82BA88C809 |
| comment | FUNCTION Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.SUBUNIT Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (PubMed:16622419). The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX (PubMed:9645950). Interacts with DNMT3B (PubMed:19482874). Interacts directly with CENPA (PubMed:19503796). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Interacts with MEIKIN (By similarity).INTERACTION Localizes exclusively in the kinetochore domain of centromeres.ALTERNATIVE PRODUCTS Expression varies across the cell cycle, with high levels in G2 phase (at the mRNA level).DOMAIN The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.SIMILARITY Belongs to the CENP-C/MIF2 family. |
| description | recommendedName: Centromere protein C shortName: CENP-C alternativeName: Centromere autoantigen C alternativeName: Centromere protein C 1 shortName: CENP-C 1 alternativeName: Interphase centromere complex protein 7 |
| geneName | CENPC CENPC1 ICEN7 |
| identifier | Q03188 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome DNA-binding Isopeptide bond Kinetochore Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CENPC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996478] ENSEMBL:ENSG00000145241 CENPC [Homo sapiens] |
| secondaryIdentifier | CENPC_HUMAN Q6PIR0 Q8IW27 Q9P0M5 |
| sequenceLength | 943 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973686] UniProt:Q03188-1 CENPC [Homo sapiens] [ReferenceIsoform:8973687] UniProt:Q03188-2 CENPC [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:375292] CENPC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5633512] CENPC [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q03188 CENPC (51888)
