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Details on Person p-S318,221-HuR binds mRNA

Class:IdReaction:517705
_displayNamep-S318,221-HuR binds mRNA
_doReleaseTRUE
_timestamp2016-03-19 07:25:57
authored[InstanceEdit:517580] May, B, 2010-02-17
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:517669] May, B, 2010-02-19
edited[InstanceEdit:517580] May, B, 2010-02-17
input[OtherEntity:517622] mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318 [nucleoplasm]
[EntityWithAccessionedSequence:450532] p-S221,S318-ELAVL1 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:517773] Tandem phosphorylation of serine 221 and 318 by PKC{delta} coordinates mRNA binding and nucleo-cytoplasmic shuttling of HuR
[LiteratureReference:450594] Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
modified[InstanceEdit:517800] May, B, 2010-02-19
[InstanceEdit:766133] May, B, 2010-05-21
[InstanceEdit:789692] D'Eustachio, P, 2010-05-23
[InstanceEdit:847705] May, B, 2010-05-30
[InstanceEdit:882028] May, B, 2010-06-29
[InstanceEdit:927717] May, B, 2010-08-06
[InstanceEdit:5251727] May, B, 2014-02-05
[InstanceEdit:6792722] May, Bruce, 2015-08-26
[InstanceEdit:8865034] May, Bruce, 2016-03-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namep-S318,221-HuR binds mRNA
output[Complex:517751] HuR with phosphoserine221 and phosphoserine318:mRNA Complex [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2010-09-21
reviewed[InstanceEdit:882027] Wilusz, J, 2010-06-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104268] R-HSA-517705.4
summation[Summation:517744] HuR phosphorylated on ser221 and ser318 binds AU-rich region...
(hasEvent)[Pathway:450520] HuR (ELAVL1) binds and stabilizes mRNA [Homo sapiens]
(precedingEvent)[Reaction:450387] HuR binds the CRM1 nuclear export machinery [Homo sapiens]
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No pathways have been reviewed or authored by p-S318,221-HuR binds mRNA (517705)