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Details on Person Expression of Cyclin D1

Class:Id	BlackBoxEvent:517640
_displayName	Expression of Cyclin D1
_timestamp	2018-10-31 13:48:49
authored	[InstanceEdit:517580] May, B, 2010-02-17
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:517669] May, B, 2010-02-19
edited	[InstanceEdit:517580] May, B, 2010-02-17
isChimeric	FALSE
literatureReference	[LiteratureReference:517773] Tandem phosphorylation of serine 221 and 318 by PKC{delta} coordinates mRNA binding and nucleo-cytoplasmic shuttling of HuR
modified	[InstanceEdit:517800] May, B, 2010-02-19 [InstanceEdit:561260] May, B, 2010-04-02 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626990] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04
name	Expression of Cyclin D1
output	[EntityWithAccessionedSequence:68328] CCND1 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:450595] HuR:mRNA complex translocates from the nucleus to the cytosol [Homo sapiens] [Reaction:450387] HuR binds the CRM1 nuclear export machinery [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:517788] Negative gene expression regulation by 'Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex [cytosol]' [PositiveGeneExpressionRegulation:517823] Positive gene expression regulation by 'HuR with phosphoserine221 and phosphoserine318:mRNA Complex [cytosol]'
regulationReference	[RegulationReference:9641432] Negative gene expression regulation by 'Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex [cytosol]' Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs [RegulationReference:9642094] Positive gene expression regulation by 'HuR with phosphoserine221 and phosphoserine318:mRNA Complex [cytosol]' Tandem phosphorylation of serine 221 and 318 by PKC{delta} coordinates mRNA binding and nucleo-cytoplasmic shuttling of HuR
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8909427] R-HSA-517640.1
summation	[Summation:517765] The Cyclin D1 gene is transcribed to yield mRNA and the mRNA... [Summation:517792] HuR phosphorylated on serine221 and serine318 by protein kin... [Summation:517814] AUF1 binds an AU-rich element in the mRNA encoding cyclin D1...
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No pathways have been reviewed or authored by Expression of Cyclin D1 (517640)