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Details on Person Expression of GM-CSF

Class:Id	BlackBoxEvent:517588
_displayName	Expression of GM-CSF
_timestamp	2018-10-31 14:02:21
authored	[InstanceEdit:517580] May, B, 2010-02-17
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:517669] May, B, 2010-02-19
edited	[InstanceEdit:517580] May, B, 2010-02-17
isChimeric	FALSE
literatureReference	[LiteratureReference:517574] Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor [LiteratureReference:517660] Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes [LiteratureReference:517656] A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation [LiteratureReference:517591] Regulation of gene expression of M-, G-, GM-, and multi-CSF in normal and malignant hematopoietic cells
modified	[InstanceEdit:517800] May, B, 2010-02-19 [InstanceEdit:561260] May, B, 2010-04-02 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9626993] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04
name	Expression of GM-CSF
output	[EntityWithAccessionedSequence:517562] CSF2 [extracellular region] [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:517790] Negative gene expression regulation by 'TTP:mRNA Degradation Complex [cytosol]' [NegativeGeneExpressionRegulation:517797] Negative gene expression regulation by 'BRF1:mRNA Degradation Complex [cytosol]' [NegativeGeneExpressionRegulation:517801] Negative gene expression regulation by 'Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex [cytosol]'
regulationReference	[RegulationReference:9641709] Negative gene expression regulation by 'Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex [cytosol]' Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1 [RegulationReference:9642210] Negative gene expression regulation by 'TTP:mRNA Degradation Complex [cytosol]' TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements [RegulationReference:9642893] Negative gene expression regulation by 'BRF1:mRNA Degradation Complex [cytosol]' The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8920500] R-HSA-517588.1
summation	[Summation:517659] The GM-CSF gene is transcribed to yield mRNA which is transl... [Summation:517817] TTP binds an AU-rich element in the mRNA encoding GM-CSF and... [Summation:517812] AUF1 binds an AU-rich element in the mRNA encoding GM-CSF an... [Summation:517795] Butyrate response factor-1 (BRF1) binds an AU-rich element i...
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No pathways have been reviewed or authored by Expression of GM-CSF (517588)