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Details on Person UniProt:P42081 CD86
| Class:Id | ReferenceGeneProduct:51706 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-329 added on Fri February 6 2015 |
| _displayName | UniProt:P42081 CD86 |
| _timestamp | 2026-02-20 21:57:31 |
| chain | signal peptide:1-23 chain:24-329 |
| checksum | C249DAEEB889D911 |
| comment | FUNCTION Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:12196291, PubMed:7694363). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291, PubMed:7694363). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:11279501).FUNCTION Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.FUNCTION (Microbial infection) Acts as a receptor for adenovirus subgroup B.SUBUNIT Homodimer (PubMed:12606712). Interacts with MARCH8 (PubMed:12582153). Interacts (via cytoplasmic domain) with PHB1 and PHB2; the interactions increases after priming with CD40 (By similarity).SUBUNIT (Microbial infection) Interacts with adenovirus subgroup b fiber protein.SUBUNIT (Microbial infection) Interacts with Orthopoxvirus OPG038/M2 protein, inhibiting the interaction with CTLA4 and CD28.INTERACTION Expressed on the surfaces of antigen-presenting cells.PTM Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.ONLINE INFORMATION CD86 entry |
| description | recommendedName: T-lymphocyte activation antigen CD86 alternativeName: Activation B7-2 antigen alternativeName: B70 alternativeName: BU63 alternativeName: CTLA-4 counter-receptor B7.2 alternativeName: FUN-1 cdAntigenNameCD86/cdAntigenName |
| geneName | CD86 CD28LG2 |
| identifier | P42081 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Alternative splicing Cell membrane Disulfide bond Glycoprotein Host cell receptor for virus entry Host-virus interaction Immunity Immunoglobulin domain Membrane Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CD86 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6785057] ENSEMBL:ENSG00000114013 CD86 [Homo sapiens] |
| secondaryIdentifier | CD86_HUMAN A0N0P0 B7Z2F3 B7Z702 E7ETN5 E9PC27 Q13655 Q6FHB1 Q6GTS4 Q7M4L5 |
| sequenceLength | 329 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145189] UniProt:P42081-2 CD86 [Homo sapiens] [ReferenceIsoform:222487] UniProt:P42081-3 CD86 [Homo sapiens] [ReferenceIsoform:403999] UniProt:P42081-1 CD86 [Homo sapiens] [ReferenceIsoform:8966924] UniProt:P42081-4 CD86 [Homo sapiens] [ReferenceIsoform:8966925] UniProt:P42081-5 CD86 [Homo sapiens] [ReferenceIsoform:8966926] UniProt:P42081-6 CD86 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:179784] CD86 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P42081 CD86 (51706)
