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Details on Person UniProt:P08962 CD63
| Class:Id | ReferenceGeneProduct:51684 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-238 added on Fri February 6 2015;initiator methionine:1 for 51684 removed on Fri Nov 03 2023;initiator methionine: for 51684 added on Fri Nov 03 2023;initiator methionine: for 51684 removed on Fri Aug 15 2025;initiator methionine:1 for 51684 added on Fri Aug 15 2025 |
| _displayName | UniProt:P08962 CD63 |
| _timestamp | 2025-08-15 21:28:50 |
| chain | initiator methionine:1 chain:2-238 |
| checksum | 85AC8E235C6E425F |
| comment | FUNCTION Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.SUBUNIT Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1 (PubMed:16917503, PubMed:24635319). Interacts with CD9. Identified in a complex with CD9 and ITGB3 (PubMed:19640571). Interacts with PMEL (PubMed:21962903). Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes (PubMed:23632027). Interacts with SYT7 (By similarity).INTERACTION Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).ALTERNATIVE PRODUCTS Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.PTM Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).MISCELLANEOUS Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.MISCELLANEOUS This antigen is associated with early stages of melanoma tumor progression.SIMILARITY Belongs to the tetraspanin (TM4SF) family. |
| description | recommendedName: CD63 antigen alternativeName: Granulophysin alternativeName: fullName evidence="19 21"Lysosomal-associated membrane protein 3 shortName evidence="19 21"LAMP-3 alternativeName: fullName evidence="21"Lysosome integral membrane protein 1 shortName evidence="21"Limp1 alternativeName: fullName evidence="20 21"Melanoma-associated antigen ME491 alternativeName: OMA81H alternativeName: Ocular melanoma-associated antigen alternativeName: Tetraspanin-30 shortName: Tspan-30 cdAntigenNameCD63/cdAntigenName |
| geneName | CD63 MLA1 TSPAN30 |
| identifier | P08962 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Direct protein sequencing Endosome Glycoprotein Lipoprotein Lysosome Membrane Palmitate Protein transport Proteomics identification Reference proteome Secreted Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CD63 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996475] ENSEMBL:ENSG00000135404 CD63 [Homo sapiens] |
| secondaryIdentifier | CD63_HUMAN F8VZE2 Q5TZP3 Q8N6Z9 Q9UCG6 |
| sequenceLength | 238 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8964722] UniProt:P08962-1 CD63 [Homo sapiens] [ReferenceIsoform:8964723] UniProt:P08962-2 CD63 [Homo sapiens] [ReferenceIsoform:8964724] UniProt:P08962-3 CD63 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:51683] CD63 [platelet dense granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:114583] CD63 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799157] CD63 [azurophil granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P08962 CD63 (51684)
