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Details on Person UniProt:P08571 CD14
| Class:Id | ReferenceGeneProduct:51618 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Sat February 7 2015;chain:20-367 added on Sat February 7 2015;chain:20-345 added on Sat February 7 2015;propeptide:346-375 added on Sat February 7 2015 |
| _displayName | UniProt:P08571 CD14 |
| _timestamp | 2024-11-03 19:40:16 |
| chain | signal peptide:1-19 chain:20-367 chain:20-345 propeptide:346-375 |
| checksum | 1746CDB41F394F8D |
| comment | FUNCTION Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).SUBUNIT Interacts with LPS-bound LPB (PubMed:1698311, PubMed:23264655). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Interacts with LPAR1 (By similarity). Interacts with the TLR2:TLR6 or TLR2:TLR1 heterodimers; upon interaction with ligands such as diacylated lipopeptides and triacylated lipopeptides, respectively (PubMed:16880211). Interacts with MYO18A (PubMed:25965346). Interacts with FSTL1 (PubMed:22265692).INTERACTION Secreted forms may arise by cleavage of the GPI anchor.TISSUE SPECIFICITY Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.INDUCTION The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced.DOMAIN The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.PTM N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.ONLINE INFORMATION CD14 entry |
| description | recommendedName: fullName evidence="20"Monocyte differentiation antigen CD14 alternativeName: fullName evidence="19"My23 antigen alternativeName: Myeloid cell-specific leucine-rich glycoprotein cdAntigenNameCD14/cdAntigenName component recommendedName: Monocyte differentiation antigen CD14, urinary form /component component recommendedName: Monocyte differentiation antigen CD14, membrane-bound form /component |
| geneName | CD14 |
| identifier | P08571 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Golgi apparatus GPI-anchor Immunity Inflammatory response Innate immunity Leucine-rich repeat Lipoprotein Membrane Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CD14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004019] ENSEMBL:ENSG00000170458 CD14 [Homo sapiens] |
| secondaryIdentifier | CD14_HUMAN Q53XT5 Q96FR6 Q96L99 Q9UNS3 |
| sequenceLength | 375 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:166025] CD14(20-345) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:166033] GPIN-CD14(20-345) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2201284] GPIN-CD14(20-345) [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803315] GPIN-CD14(20-345) [secretory granule membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:166032] N-asparaginyl-glycosylphosphatidylinositolethanolamine at 345 |
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No pathways have been reviewed or authored by UniProt:P08571 CD14 (51618)
