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Details on Person UniProt:P49682-1 CXCR3
| Class:Id | ReferenceIsoform:51600 |
|---|---|
| _chainChangeLog | chain:1-368 added on Sat February 7 2015 |
| _displayName | UniProt:P49682-1 CXCR3 |
| _timestamp | 2024-11-03 19:50:39 |
| chain | chain:1-368 |
| checksum | F08A3B44B2BBAD04 |
| comment | FUNCTION Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling.FUNCTION Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.FUNCTION Mediates the activity of CXCL11.SUBUNIT Homomer. Forms heteromers with ACKR4.SUBUNIT Interacts with PF4/CXCL4.SUBUNIT Interacts with PF4/CXCL4.INTERACTION Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).PTM Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.PTM N-glycosylated.MISCELLANEOUS Due to exon skipping.SIMILARITY Belongs to the G-protein coupled receptor 1 family.ONLINE INFORMATION CXC chemokine receptors entry |
| description | recommendedName: C-X-C chemokine receptor type 3 shortName: CXC-R3 shortName: CXCR-3 alternativeName: CKR-L2 alternativeName: G protein-coupled receptor 9 alternativeName: Interferon-inducible protein 10 receptor shortName: IP-10 receptor cdAntigenNameCD183/cdAntigenName |
| geneName | CXCR3 GPR9 |
| identifier | P49682 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Angiogenesis Apoptosis Cell membrane Chemotaxis Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Sulfation Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CXCR3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004643] ENSEMBL:ENSG00000186810 CXCR3 [Homo sapiens] |
| secondaryIdentifier | CXCR3_HUMAN B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5 |
| sequenceLength | 368 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P49682-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:9943832] CXCR3 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P49682-1 CXCR3 (51600)
