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Details on Person UniProt:P54284 CACNB3
| Class:Id | ReferenceGeneProduct:51564 |
|---|---|
| _chainChangeLog | chain:1-484 added on Sat February 7 2015 |
| _displayName | UniProt:P54284 CACNB3 |
| _timestamp | 2024-11-03 19:50:10 |
| chain | chain:1-484 |
| checksum | 19CD3549F5A8E17A |
| comment | FUNCTION Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).SUBUNIT Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1 (PubMed:29742403). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio (Probable). Interacts with CACNA2D4 (PubMed:12181424). Interacts with FASLG (PubMed:19807924). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel (By similarity).INTERACTION Expressed mostly in brain, colon and ovary.SIMILARITY Belongs to the calcium channel beta subunit family. |
| description | recommendedName: Voltage-dependent L-type calcium channel subunit beta-3 shortName: CAB3 alternativeName: Calcium channel voltage-dependent subunit beta 3 |
| geneName | CACNB3 CACNLB3 |
| identifier | P54284 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Calcium channel Calcium transport Cytoplasm Ion channel Ion transport Phosphoprotein Proteomics identification Reference proteome SH3 domain Transport Voltage-gated channel |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CACNB3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998195] ENSEMBL:ENSG00000167535 CACNB3 [Homo sapiens] |
| secondaryIdentifier | CACB3_HUMAN A8K0Z4 B7Z4Q1 B7Z973 B7ZAK8 F5GZW7 F5H2P6 F8VSG3 Q13913 |
| sequenceLength | 484 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145110] UniProt:P54284-2 CACNB3 [Homo sapiens] [ReferenceIsoform:404388] UniProt:P54284-1 CACNB3 [Homo sapiens] [ReferenceIsoform:8965996] UniProt:P54284-3 CACNB3 [Homo sapiens] [ReferenceIsoform:8965997] UniProt:P54284-4 CACNB3 [Homo sapiens] [ReferenceIsoform:8965998] UniProt:P54284-5 CACNB3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:210401] CACNB3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:532201] CACNB3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P54284 CACNB3 (51564)
