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Details on Person UniProt:O95503 CBX6
| Class:Id | ReferenceGeneProduct:51526 |
|---|---|
| _chainChangeLog | chain:1-412 added on Fri February 6 2015 |
| _displayName | UniProt:O95503 CBX6 |
| _timestamp | 2024-11-03 20:18:16 |
| chain | chain:1-412 |
| checksum | 50C69233B9ADEEA3 |
| comment | FUNCTION Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).SUBUNIT Component of a PRC1-like complex (PubMed:21282530). Distinct PRC1-like core complexes are composed of a RING1 subunit (RING1B or RING1A), one of the six PCGF proteins (PCGF1-6), one PHC protein (PHC1-3) and one of the CBX proteins (CBX2, CBX4, CBX6, CBX7 or CBX8) (PubMed:21282530). Interacts with PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, RING1 and RNF2 (PubMed:18927235, PubMed:21282530). May interact with H3C15 and H3C1 (PubMed:18927235). Interacts (via chromodomain) with single-stranded RNA (ssRNA) (By similarity).INTERACTION Uniformely distributed in the nucleoplasm (PubMed:18927235). Localizes to the inactivated X chromosome in females (By similarity).DEVELOPMENTAL STAGE Expressed during interphase and metaphase.PTM Ubiquitinated. Ubiquitination regulates the function of the Polycomb group (PcG) multiprotein PRC1-like complex. Deubiquitinated by USP26.MISCELLANEOUS The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. |
| description | recommendedName: Chromobox protein homolog 6 |
| geneName | CBX6 |
| identifier | O95503 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chromatin regulator Chromosome Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CBX6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998782] ENSEMBL:ENSG00000183741 CBX6 [Homo sapiens] |
| secondaryIdentifier | CBX6_HUMAN A8KAH0 Q96EM5 |
| sequenceLength | 412 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:3229071] CBX6 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95503 CBX6 (51526)
