Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q14781 CBX2
| Class:Id | ReferenceGeneProduct:51518 |
|---|---|
| _chainChangeLog | chain:1-532 added on Fri February 6 2015 |
| _displayName | UniProt:Q14781 CBX2 |
| _timestamp | 2024-11-03 20:18:15 |
| chain | chain:1-532 |
| checksum | 3DB58A654568BDD4 |
| comment | FUNCTION Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).SUBUNIT Component of a PRC1-like complex (PubMed:12167701, PubMed:19636380, PubMed:21282530). The composition of the PRC1 complex may differ between the PRC1 complex in pluripotent embryonic stem cells containing RNF2, CBX7 and PCGF2, and the PRC1 complex in differentiating cells containing RNF2, CBX2, CBX4 and BMI1 (By similarity). May interact with H3C15, H3C1 and RNF2 (PubMed:18927235). Interacts (via chromodomain) with histone H3K9Me3 and H3K27me3 (By similarity).INTERACTION Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin.ALTERNATIVE PRODUCTS Expressed during interphase and metaphase.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes. |
| description | recommendedName: Chromobox protein homolog 2 |
| geneName | CBX2 |
| identifier | Q14781 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chromatin regulator Chromosome Differentiation Disease variant DNA-binding Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Sexual differentiation Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CBX2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957980] ENSEMBL:ENSG00000173894 CBX2 [Homo sapiens] |
| secondaryIdentifier | CBX2_HUMAN Q0VDA5 Q9BTB1 |
| sequenceLength | 532 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:221627] UniProt:Q14781-2 CBX2 [Homo sapiens] [ReferenceIsoform:405747] UniProt:Q14781-1 CBX2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:389110] CBX2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8958169] CBX2 [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q14781 CBX2 (51518)
