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Details on Person UniProt:P83917 Cbx1
| Class:Id | ReferenceGeneProduct:51516 |
|---|---|
| _chainChangeLog | chain:1-185 added on Fri February 6 2015 |
| _displayName | UniProt:P83917 Cbx1 |
| _timestamp | 2026-02-20 22:52:37 |
| chain | chain:1-185 |
| checksum | BE687AF9C66E48E3 |
| comment | FUNCTION Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:11242053). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (By similarity). Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane (PubMed:11571267).SUBUNIT Homodimer (PubMed:10747027). Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain (PubMed:10562550, PubMed:10747027, PubMed:8978696). Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain (PubMed:11571267). Interacts with SUV39H1, SETDB1, KMT5B and KMT5C (PubMed:10202156, PubMed:15145825). Interacts with PRDM6 (PubMed:16537907). Interacts with POGZ (By similarity). Interacts with CHAMP1 (By similarity). Interacts with INCENP (By similarity). Interacts with SGO1; the CBX1 homodimer binds to one molecule of SGO1 (By similarity). Interacts with LRIF1 (via PxVxL motif) (By similarity). Interacts with HDGFL2 (By similarity). Interacts with CHD3 (By similarity). Interacts with CHD4 (By similarity).INTERACTION Unassociated with chromosomes during mitosis.TISSUE SPECIFICITY In all adult and embryonic tissues.PTM Not phosphorylated.PTM Ubiquitinated. |
| description | recommendedName: Chromobox protein homolog 1 alternativeName: Heterochromatin protein 1 homolog beta shortName: HP1 beta alternativeName: Heterochromatin protein p25 alternativeName: M31 alternativeName: Modifier 1 protein |
| geneName | Cbx1 Cbx |
| identifier | P83917 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Isopeptide bond Nucleus Phosphoprotein Reference proteome Repeat Ubl conjugation |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Cbx1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CBX1_MOUSE P23197 |
| sequenceLength | 185 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9940385] Cbx1 [nucleoplasm] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P83917 Cbx1 (51516)
