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Details on Person UniProt:P35520 CBS

Class:Id	ReferenceGeneProduct:51512
_chainChangeLog	initiator methionine:1 added on Sat February 7 2015;chain:2-551 added on Sat February 7 2015
_displayName	UniProt:P35520 CBS
_timestamp	2025-02-21 19:57:05
chain	chain:1-551
checksum	F89E69C67BDE6701
comment	FUNCTION Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).CATALYTIC ACTIVITY L-homocysteine + L-serine = L,L-cystathionine + H2OCOFACTOR Allosterically activated by S-adenosyl-methionine/AdoMet. Activated by S-adenosylhomocysteine/AdoHcy (PubMed:20506325). Binds non-covalently to a heme group that may control the redox sensitivity of the enzyme (PubMed:11483494, PubMed:12173932, PubMed:22738154).PATHWAY Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.SUBUNIT Homotetramer.INTERACTION In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cysteine synthase/cystathionine beta-synthase family.
description	recommendedName: fullName evidence="48"Cystathionine beta-synthase ecNumber evidence="24 28 29 30"4.2.1.22 alternativeName: Beta-thionase alternativeName: Serine sulfhydrase
geneName	CBS
identifier	P35520
isSequenceChanged	FALSE
keyword	3D-structure Allosteric enzyme Alternative splicing Amino-acid biosynthesis CBS domain Cysteine biosynthesis Cytoplasm Disease variant Heme Iron Isopeptide bond Lyase Metal-binding Nucleus Phosphoprotein Proteomics identification Pyridoxal phosphate Reference proteome Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	CBS
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8998199] ENSEMBL:ENSG00000160200 CBS [Homo sapiens]
secondaryIdentifier	CBS_HUMAN B2R993 D3DSK4 Q99425 Q9BWC5
sequenceLength	551
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:145015] UniProt:P35520-2 CBS [Homo sapiens] [ReferenceIsoform:403828] UniProt:P35520-1 CBS [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:1614563] PXLP-K119-CBS [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:4655401] monoSUMO1-K211-PXLP-CBS [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4655441] PXLP-CBS [nucleoplasm] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:1614625] N6-pyridoxal phosphate-L-lysine at 119 [GroupModifiedResidue:4655325] sumoylated lysine (monoSUMO1 [nucleoplasm]) at 211
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No pathways have been reviewed or authored by UniProt:P35520 CBS (51512)