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Details on Person GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

Class:Id	Reaction:514604
_displayName	GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)
_doRelease	TRUE
_timestamp	2025-12-16 18:01:27
authored	[InstanceEdit:514615] D'Eustachio, P, 2010-02-17
catalystActivity	[CatalystActivity:514632] GMP reductase activity of GMPR tetramers [cytosol]
catalystActivityReference	[CatalystActivityReference:9643147] GMP reductase activity of GMPR tetramers [cytosol] Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:514616] D'Eustachio, P, 2010-02-17
crossReference	[DatabaseIdentifier:9976258] RHEA:17187
edited	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
input	[SimpleEntity:113578] GMP [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
isChimeric	FALSE
literatureReference	[LiteratureReference:514607] NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties [LiteratureReference:514622] Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP [LiteratureReference:514627] Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators
modified	[InstanceEdit:514635] D'Eustachio, P, 2010-02-17 [InstanceEdit:532423] D'Eustachio, P, 2010-02-26 [InstanceEdit:532680] D'Eustachio, P, 2010-03-02 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9731667] D'Eustachio, Peter, 2021-05-21 [InstanceEdit:9737497] D'Eustachio, Peter, 2021-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) GMP + NADPH + 2 H(+) => IMP + NH4(+) + NADP(+)
output	[SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:31633] NH4+ [cytosol] [SimpleEntity:29602] IMP [cytosol]
precedingEvent	[Reaction:74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-03-16
reviewed	[InstanceEdit:165071] Graves, L, Rush, MG, 0000-00-00 00:00:00 [InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104223] R-HSA-514604.6
structureModified	[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
summation	[Summation:514623] Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP...
(hasEvent)	[Pathway:74217] Purine salvage [Homo sapiens]
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No pathways have been reviewed or authored by GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (514604)