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Details on Person UniProt:Q03135 CAV1
| Class:Id | ReferenceGeneProduct:51448 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-178 added on Fri February 6 2015;initiator methionine: for 51448 added on Sun February 16 2020;initiator methionine:1 for 51448 removed on Fri Nov 03 2023;initiator methionine: for 51448 removed on Fri Aug 15 2025;initiator methionine: for 51448 removed on Fri Aug 15 2025;initiator methionine:1 for 51448 added on Fri Aug 15 2025;initiator methionine:1 for 51448 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q03135 CAV1 |
| _timestamp | 2026-02-20 22:30:22 |
| chain | initiator methionine:1 chain:2-178 initiator methionine:1 |
| checksum | 2424DE9B5E6521D5 |
| comment | FUNCTION May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity).SUBUNIT Homooligomer (PubMed:25588833). Interacts with GLIPR2 (PubMed:11865038). Interacts with NOSTRIN (PubMed:16807357). Interacts with SNAP25 and STX1A (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct (PubMed:17287217). Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with SLC7A9 (By similarity). Interacts with BMX and BTK (PubMed:11751885). Interacts with TGFBR1 (PubMed:25893292). Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner (PubMed:19262564, PubMed:25588833). Interacts with CAVIN1 (PubMed:25588833). Interacts with EHD2 in a cholesterol-dependent manner (PubMed:25588833). Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation (PubMed:21822278, PubMed:23335559). Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (PubMed:24576892). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity). Interacts with IGFBP5; this interaction allows trafficking of IGFBP5 from the plasma membrane to the nucleus (PubMed:20345844).SUBUNIT (Microbial infection) Interacts with rotavirus A NSP4.SUBUNIT (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) matrix protein; this interaction probably facilitates viral budding.INTERACTION Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. In the presence of DSG2 localizes to the cytoplasm away from cell borders (PubMed:26918609).ALTERNATIVE PRODUCTS Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.PTM Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination (PubMed:21822278). Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation (PubMed:23335559). Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response (PubMed:28593998).PTM The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.PTM Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the caveolin family.ONLINE INFORMATION Caveolin entry |
| description | recommendedName: Caveolin-1 |
| geneName | CAV1 CAV |
| identifier | Q03135 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative initiation Cell membrane Congenital generalized lipodystrophy Cytoplasm Diabetes mellitus Direct protein sequencing Disease variant Golgi apparatus Host-virus interaction Isopeptide bond Lipoprotein Membrane Palmitate Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CAV1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999945] ENSEMBL:ENSG00000105974 CAV1 [Homo sapiens] |
| secondaryIdentifier | CAV1_HUMAN Q9UGP1 Q9UNG1 Q9UQH6 |
| sequenceLength | 178 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:221385] UniProt:Q03135-2 CAV1 [Homo sapiens] [ReferenceIsoform:405109] UniProt:Q03135-1 CAV1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:163510] CAV1 [lipid droplet] [Homo sapiens] [EntityWithAccessionedSequence:204504] CAV1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:534994] CAV1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:535009] CAV1 [endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:5368451] CAV1 [early endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:9037089] p-Y14-CAV1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9979014] CAV1 [host caveola] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9037077] O4'-phospho-L-tyrosine at 14 |
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No pathways have been reviewed or authored by UniProt:Q03135 CAV1 (51448)
