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Query author contributions in Reactome

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Details on Person UniProt:P43234 CTSO

Class:IdReferenceGeneProduct:51438
_chainChangeLogsignal peptide:1-23 added on Fri February 6 2015;propeptide:24-107 added on Fri February 6 2015;chain:108-321 added on Fri February 6 2015
_displayNameUniProt:P43234 CTSO
_timestamp2024-11-03 20:18:15
chainsignal peptide:1-23
propeptide:24-107
chain:108-321
checksumF48011ECA9E0BC45
commentFUNCTION Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.CATALYTIC ACTIVITY The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.INTERACTION Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.SIMILARITY Belongs to the peptidase C1 family.
descriptionrecommendedName: Cathepsin O ecNumber: 3.4.22.42
geneNameCTSO
CTSO1
identifierP43234
isSequenceChangedFALSE
keywordDisulfide bond
Glycoprotein
Hydrolase
Lysosome
Protease
Proteomics identification
Reference proteome
Signal
Thiol protease
Zymogen
modified[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:2455454] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:8987656] Weiser, JD
[InstanceEdit:9037114] Weiser, JD
[InstanceEdit:9637257] Weiser, JD
[InstanceEdit:9676415] Weiser, JD
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameCTSO
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9000490] ENSEMBL:ENSG00000256043 CTSO [Homo sapiens]
secondaryIdentifierCATO_HUMAN
sequenceLength321
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:1181227] CTSO [lysosomal lumen] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P43234 CTSO (51438)