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Details on Person UniProt:P43235 CTSK
| Class:Id | ReferenceGeneProduct:51434 |
|---|---|
| _chainChangeLog | signal peptide:1-15 added on Sat February 7 2015;propeptide:16-114 added on Sat February 7 2015;chain:115-329 added on Sat February 7 2015 |
| _displayName | UniProt:P43235 CTSK |
| _timestamp | 2024-11-03 19:40:13 |
| chain | signal peptide:1-15 propeptide:16-114 chain:115-329 |
| checksum | 4677C3C89FF4CE85 |
| comment | FUNCTION Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).CATALYTIC ACTIVITY Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.SUBCELLULAR LOCATION Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.TISSUE SPECIFICITY Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase C1 family. |
| description | recommendedName: Cathepsin K ecNumber: 3.4.22.38 alternativeName: Cathepsin O alternativeName: Cathepsin O2 alternativeName: Cathepsin X |
| geneName | CTSK CTSO CTSO2 |
| identifier | P43235 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disease variant Disulfide bond Glycoprotein Hydrolase Lysosome Membrane Protease Proteomics identification Reference proteome Secreted Signal Thiol protease Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CTSK |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995881] ENSEMBL:ENSG00000143387 CTSK [Homo sapiens] |
| secondaryIdentifier | CATK_HUMAN Q6FHS6 |
| sequenceLength | 329 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1181226] CTSK [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:1678985] CTSK [endolysosome lumen] [Homo sapiens] [EntityWithAccessionedSequence:2470897] CTSK [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P43235 CTSK (51434)
