Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9UBX1 CTSF
| Class:Id | ReferenceGeneProduct:51428 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;propeptide:20-270 added on Fri February 6 2015;chain:271-484 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UBX1 CTSF |
| _timestamp | 2024-11-03 19:59:58 |
| chain | signal peptide:1-19 propeptide:20-270 chain:271-484 |
| checksum | 1D5D551B489D822B |
| comment | FUNCTION Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.CATALYTIC ACTIVITY The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L.SUBCELLULAR LOCATION High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase C1 family. |
| description | recommendedName: Cathepsin F shortName: CATSF ecNumber: 3.4.22.41 |
| geneName | CTSF |
| identifier | Q9UBX1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant Disulfide bond Glycoprotein Hydrolase Lysosome Neurodegeneration Neuronal ceroid lipofuscinosis Protease Proteomics identification Reference proteome Signal Thiol protease Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CTSF |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003420] ENSEMBL:ENSG00000174080 CTSF [Homo sapiens] |
| secondaryIdentifier | CATF_HUMAN B2R964 O95240 Q9NSU4 Q9UKQ5 |
| sequenceLength | 484 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1181231] CTSF [lysosomal lumen] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UBX1 CTSF (51428)
