Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:P07858 CTSB

Class:Id	ReferenceGeneProduct:51420
_chainChangeLog	signal peptide:1-17 added on Fri February 6 2015;propeptide:18-79 added on Fri February 6 2015;chain:80-333 added on Fri February 6 2015;chain:80-126 added on Fri February 6 2015;chain:129-333 added on Fri February 6 2015;propeptide:334-339 added on Fri February 6 2015
_displayName	UniProt:P07858 CTSB
_timestamp	2024-11-03 20:04:38
chain	signal peptide:1-17 propeptide:18-79 chain:80-333 chain:80-126 chain:129-333 propeptide:334-339
checksum	0FC818EA4C1F6D90
comment	FUNCTION Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105).CATALYTIC ACTIVITY Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-\|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.ACTIVITY REGULATION Inhibited by leupeptin.SUBUNIT Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Directly interacts with SHKBP1 (PubMed:16733801).INTERACTION Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity).TISSUE SPECIFICITY Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.DISEASE The gene represented in this entry is involved in disease pathogenesis. Tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB result in CTSB abnormal expression with pathological consequences.SIMILARITY Belongs to the peptidase C1 family.
description	recommendedName: Cathepsin B ecNumber evidence="7 16"3.4.22.1 alternativeName: APP secretase shortName: APPS alternativeName: Cathepsin B1 component recommendedName: fullName evidence="18"Cathepsin B light chain /component component recommendedName: fullName evidence="18"Cathepsin B heavy chain /component
geneName	CTSB CPSB
identifier	P07858
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Membrane Protease Proteomics identification Reference proteome Secreted Signal Thiol protease Zymogen
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	CTSB
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8958143] ENSEMBL:ENSG00000164733 CTSB [Homo sapiens]
secondaryIdentifier	CATB_HUMAN B3KQR5 B3KRR5 Q503A6 Q96D87
sequenceLength	339
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:1181222] CTSB(80-333) [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:1679058] CTSB(80-333) [endolysosome lumen] [Homo sapiens] [EntityWithAccessionedSequence:2228661] CTSB(80-126) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:2471625] CTSB(129-333) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6801299] CTSB(80-333) [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801608] CTSB(80-333) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8957839] CTSB [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9935545] CTSB(129-333) [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:9935549] CTSB(80-126) [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:9958429] CTSB(80-333) [late endosome lumen] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:P07858 CTSB (51420)