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Details on Person UniProt:P04040 CAT
| Class:Id | ReferenceGeneProduct:51418 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-527 added on Fri February 6 2015;initiator methionine:1 for 51418 removed on Fri Nov 03 2023;initiator methionine: for 51418 added on Fri Nov 03 2023;initiator methionine: for 51418 removed on Fri Aug 15 2025;initiator methionine:1 for 51418 added on Fri Aug 15 2025 |
| _displayName | UniProt:P04040 CAT |
| _timestamp | 2025-08-15 21:13:24 |
| chain | initiator methionine:1 chain:2-527 |
| checksum | 7BAA2394D124ED20 |
| comment | FUNCTION Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369).CATALYTIC ACTIVITY 2 H2O2 = O2 + 2 H2OCOFACTOR Homotetramer (PubMed:10656833, PubMed:10666617, PubMed:21976670). Interacts (via microbody targeting signal) with PEX5, monomeric form interacts with PEX5, leading to its translocation into peroxisomes (PubMed:21976670).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the catalase family.ONLINE INFORMATION Catalase entry |
| description | recommendedName: Catalase ecNumber evidence="8"1.11.1.6 |
| geneName | CAT |
| identifier | P04040 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Heme Hydrogen peroxide Iron Metal-binding Mitogen NADP Oxidoreductase Peroxidase Peroxisome Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CAT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998197] ENSEMBL:ENSG00000121691 CAT [Homo sapiens] |
| secondaryIdentifier | CATA_HUMAN A8K6C0 B2RCZ9 D3DR07 Q2M1U4 Q4VXX5 Q9BWT9 Q9UC85 |
| sequenceLength | 527 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:51417] CAT [peroxisomal matrix] [Homo sapiens] [EntityWithAccessionedSequence:6801279] CAT [ficolin-1-rich granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801311] CAT [secretory granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6801564] CAT [extracellular exosome] [Homo sapiens] [EntityWithAccessionedSequence:6806458] CAT [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9033141] CAT [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P04040 CAT (51418)
