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Details on Person UniProt:Q9NPP4 NLRC4
| Class:Id | ReferenceGeneProduct:51396 |
|---|---|
| _chainChangeLog | chain:1-1024 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NPP4 NLRC4 |
| _timestamp | 2024-11-03 19:52:51 |
| chain | chain:1-1024 |
| checksum | 49378DBB54938E0F |
| comment | FUNCTION Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).SUBUNIT Homooligomer; homooligomerizes to induce formation of the NLRC4 inflammasome (PubMed:25385754, PubMed:33420028). Homooligomerizes following activation by pathogenic proteins (By similarity). Component of the NLRC4 inflammasome, at least composed of NLRC4 and caspase-1 (CASP1) (By similarity). Some NLRC4 inflammasomes contain PYCARD/ASC, while some others directly contact and activate CASP1 (PubMed:25217959). Interacts (via CARD domain) with PYCARD/ASC, pro-caspase-1 (CASP1), NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction (PubMed:15107016). Interacts with EIF2AK2/PKR (PubMed:22801494).INTERACTION Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.DOMAIN In an autoinhibited form the C-terminal leucine-rich repeat (LRR) domain is positioned to sterically occlude one side of the NBD domain and consequently sequester NLRC4 in a monomeric state. An ADP-mediated interaction between the NBD and the WHD also contributes to the autoinhibition.PTM Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: NLR family CARD domain-containing protein 4 alternativeName: CARD, LRR, and NACHT-containing protein shortName evidence="14"CED-4-like protein Clan alternativeName: fullName evidence="12"Caspase recruitment domain-containing protein 12 alternativeName: fullName evidence="13"Ice protease-activating factor shortName evidence="13"Ipaf |
| geneName | NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215 |
| identifier | Q9NPP4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis ATP-binding Cytoplasm Disease variant Immunity Inflammasome Inflammatory response Innate immunity Leucine-rich repeat Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NLRC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6801362] ENSEMBL:ENSG00000091106 NLRC4 [Homo sapiens] |
| secondaryIdentifier | NLRC4_HUMAN A8K9F8 B2RBQ3 B3KTF0 D6W580 Q96J81 Q96J82 Q96J83 |
| sequenceLength | 1024 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144972] UniProt:Q9NPP4-2 NLRC4 [Homo sapiens] [ReferenceIsoform:144973] UniProt:Q9NPP4-3 NLRC4 [Homo sapiens] [ReferenceIsoform:144974] UniProt:Q9NPP4-4 NLRC4 [Homo sapiens] [ReferenceIsoform:414662] UniProt:Q9NPP4-1 NLRC4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:561198] NLRC4 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NPP4 NLRC4 (51396)
