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| Class:Id | ReferenceGeneProduct:51374 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-248 added on Fri February 6 2015;propeptide:249-251 added on Fri February 6 2015;signal peptide:1-26 removed on Fri February 12 2016;signal peptide:1-19 added on Fri February 12 2016;propeptide:20-26 added on Fri February 12 2016;propeptide:25-26 added on Fri February 12 2016 |
| _displayName | UniProt:P20160 AZU1 |
| _timestamp | 2024-11-03 20:18:13 |
| chain | signal peptide:1-19 propeptide:20-26 propeptide:25-26 chain:27-248 propeptide:249-251 |
| checksum | 22F80D9EBE87DE60 |
| comment | FUNCTION This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.SUBCELLULAR LOCATION Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides.PTM Cleavage of the N-terminal propeptide which is composed of 7 amino acids occurs in two steps. The initial cleavage of 5 amino acids is followed by the cleavage of a dipeptide to produce the mature form.SIMILARITY Belongs to the peptidase S1 family. Elastase subfamily. |
| description | recommendedName: fullName evidence="20"Azurocidin alternativeName: fullName evidence="19"Cationic antimicrobial protein CAP37 alternativeName: fullName evidence="18"Heparin-binding protein shortName evidence="18"HBP shortName evidence="18"hHBP |
| geneName | AZU1 |
| identifier | P20160 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Antibiotic Antimicrobial Chemotaxis Direct protein sequencing Disulfide bond Glycoprotein Heparin-binding Membrane Proteomics identification Reference proteome Serine protease homolog Signal Zymogen |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | AZU1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992922] ENSEMBL:ENSG00000172232 AZU1 [Homo sapiens] |
| secondaryIdentifier | CAP7_HUMAN P80014 Q52LG4 Q9UCM1 Q9UCT5 |
| sequenceLength | 251 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6798767] AZU1 [azurophil granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6806193] AZU1 [extracellular region] [Homo sapiens] |
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