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Details on Person Diagram of DNA Double Strand Break Response, Defective DNA double strand break response due to BRCA1 loss of function, and Defective DNA double strand break response due to BARD1 loss of function
| Class:Id | PathwayDiagram:512996 |
|---|---|
| _displayName | Diagram of DNA Double Strand Break Response, Defective DNA double strand break response due to BRCA1 loss of function, and Defective DNA double strand break response due to BARD1 loss of function |
| _timestamp | 2026-05-14 19:15:33 |
| created | [InstanceEdit:512997] Matthews, L, 2010-02-16 |
| height | 1944 |
| modified | [InstanceEdit:549333] Matthews, L, 2010-03-19 [InstanceEdit:622317] Matthews, L, 2010-04-22 [InstanceEdit:708318] Matthews, L, 2010-05-11 [InstanceEdit:5658491] Orlic-Milacic, Marija, 2014-12-19 [InstanceEdit:5659815] Orlic-Milacic, Marija, 2014-12-23 [InstanceEdit:5659857] Orlic-Milacic, Marija, 2014-12-23 [InstanceEdit:5675884] Orlic-Milacic, Marija, 2015-02-17 [InstanceEdit:5678231] Matthews, Lisa, 2015-02-23 [InstanceEdit:5682052] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5682056] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5682138] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5682156] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5682177] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5682181] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5682188] Orlic-Milacic, Marija, 2015-03-05 [InstanceEdit:5682491] Orlic-Milacic, Marija, 2015-03-06 [InstanceEdit:5682523] Orlic-Milacic, Marija, 2015-03-07 [InstanceEdit:5682535] Orlic-Milacic, Marija, 2015-03-07 [InstanceEdit:5682536] Orlic-Milacic, Marija, 2015-03-07 [InstanceEdit:5682565] Orlic-Milacic, Marija, 2015-03-09 [InstanceEdit:5682584] Orlic-Milacic, Marija, 2015-03-09 [InstanceEdit:5682597] Orlic-Milacic, Marija, 2015-03-09 [InstanceEdit:5682605] Orlic-Milacic, Marija, 2015-03-09 [InstanceEdit:5682616] Orlic-Milacic, Marija, 2015-03-09 [InstanceEdit:5682618] Orlic-Milacic, Marija, 2015-03-09 [InstanceEdit:5682633] Orlic-Milacic, Marija, 2015-03-09 [InstanceEdit:5682836] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5682865] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5682962] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5682964] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5682986] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5682987] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5682994] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5683001] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5683052] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5683080] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5683081] Orlic-Milacic, Marija, 2015-03-11 [InstanceEdit:5683093] Orlic-Milacic, Marija, 2015-03-12 [InstanceEdit:5683391] Orlic-Milacic, Marija, 2015-03-13 [InstanceEdit:5683392] Orlic-Milacic, Marija, 2015-03-13 [InstanceEdit:5683427] Orlic-Milacic, Marija, 2015-03-13 [InstanceEdit:5683608] Orlic-Milacic, Marija, 2015-03-16 [InstanceEdit:5683730] Orlic-Milacic, Marija, 2015-03-16 [InstanceEdit:5683743] Orlic-Milacic, Marija, 2015-03-16 [InstanceEdit:5683780] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683797] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683810] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683845] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683856] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683938] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683975] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683985] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683991] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5683994] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5684013] Orlic-Milacic, Marija, 2015-03-17 [InstanceEdit:5684068] Orlic-Milacic, Marija, 2015-03-18 [InstanceEdit:5684078] Orlic-Milacic, Marija, 2015-03-18 [InstanceEdit:5684106] Orlic-Milacic, Marija, 2015-03-19 [InstanceEdit:5684110] Orlic-Milacic, Marija, 2015-03-19 [InstanceEdit:5684113] Orlic-Milacic, Marija, 2015-03-19 [InstanceEdit:5684143] Orlic-Milacic, Marija, 2015-03-19 [InstanceEdit:5684155] Orlic-Milacic, Marija, 2015-03-19 [InstanceEdit:5684860] Orlic-Milacic, Marija, 2015-03-23 [InstanceEdit:5684861] Orlic-Milacic, Marija, 2015-03-23 [InstanceEdit:5684879] Orlic-Milacic, Marija, 2015-03-23 [InstanceEdit:5684885] Orlic-Milacic, Marija, 2015-03-23 [InstanceEdit:5685032] Orlic-Milacic, Marija, 2015-03-24 [InstanceEdit:5685049] Orlic-Milacic, Marija, 2015-03-24 [InstanceEdit:5685056] Orlic-Milacic, Marija, 2015-03-24 [InstanceEdit:5685057] Orlic-Milacic, Marija, 2015-03-24 [InstanceEdit:5685151] Orlic-Milacic, Marija, 2015-03-25 [InstanceEdit:5685154] Orlic-Milacic, Marija, 2015-03-25 [InstanceEdit:5685183] Orlic-Milacic, Marija, 2015-03-25 [InstanceEdit:5685184] Orlic-Milacic, Marija, 2015-03-25 [InstanceEdit:5685218] Orlic-Milacic, Marija, 2015-03-26 [InstanceEdit:5685240] Orlic-Milacic, Marija, 2015-03-26 [InstanceEdit:5685253] Orlic-Milacic, Marija, 2015-03-26 [InstanceEdit:5685320] Orlic-Milacic, Marija, 2015-03-26 [InstanceEdit:5685340] Orlic-Milacic, Marija, 2015-03-27 [InstanceEdit:5685344] Orlic-Milacic, Marija, 2015-03-27 [InstanceEdit:5685617] Orlic-Milacic, Marija, 2015-03-27 [InstanceEdit:5685657] Orlic-Milacic, Marija, 2015-03-27 [InstanceEdit:5685668] Orlic-Milacic, Marija, 2015-03-27 [InstanceEdit:5685841] Orlic-Milacic, Marija, 2015-03-27 [InstanceEdit:5685842] Orlic-Milacic, Marija, 2015-03-27 [InstanceEdit:5685937] Orlic-Milacic, Marija, 2015-03-30 [InstanceEdit:5686582] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5687634] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5687638] Orlic-Milacic, Marija, 2015-04-08 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 [InstanceEdit:5694648] Orlic-Milacic, Marija, 2015-05-22 [InstanceEdit:6783910] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6783913] Orlic-Milacic, Marija, 2015-06-17 [InstanceEdit:6784186] Orlic-Milacic, Marija, 2015-06-18 [InstanceEdit:6784187] Orlic-Milacic, Marija, 2015-06-18 [InstanceEdit:6790452] Orlic-Milacic, Marija, 2015-08-10 [InstanceEdit:6792496] Orlic-Milacic, Marija, 2015-08-24 [InstanceEdit:6792742] Orlic-Milacic, Marija, 2015-08-26 [InstanceEdit:6792743] Orlic-Milacic, Marija, 2015-08-26 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8863394] Orlic-Milacic, Marija, 2016-03-07 [InstanceEdit:8868794] Jupe, Steve, 2016-04-25 [InstanceEdit:9663213] Orlic-Milacic, Marija, 2019-09-27 [InstanceEdit:9663215] Orlic-Milacic, Marija, 2019-09-27 [InstanceEdit:9700825] Orlic-Milacic, Marija, 2020-09-18 [InstanceEdit:9700981] Orlic-Milacic, Marija, 2020-09-22 [InstanceEdit:9701018] Orlic-Milacic, Marija, 2020-09-23 [InstanceEdit:9701032] Orlic-Milacic, Marija, 2020-09-23 [InstanceEdit:9701033] Orlic-Milacic, Marija, 2020-09-23 [InstanceEdit:9701035] Orlic-Milacic, Marija, 2020-09-23 [InstanceEdit:9707057] Orlic-Milacic, Marija, 2020-11-10 [InstanceEdit:9707072] Orlic-Milacic, Marija, 2020-11-10 [InstanceEdit:9707284] Orlic-Milacic, Marija, 2020-11-12 [InstanceEdit:9974254] Orlic-Milacic, Marija, 2025-11-21 [InstanceEdit:9974407] Orlic-Milacic, Marija, 2025-11-21 [InstanceEdit:9988833] Rothfels, Karen, 2026-05-12 [InstanceEdit:9989064] Rothfels, Karen, 2026-05-14 |
| representedPathway | [Pathway:5693606] DNA Double Strand Break Response [Homo sapiens] [Pathway:9663199] Defective DNA double strand break response due to BRCA1 loss of function [Homo sapiens] [Pathway:9699150] Defective DNA double strand break response due to BARD1 loss of function [Homo sapiens] |
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/> </Outputs> <Properties> <displayName>HERC2 and PIAS4 are recruited to DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1547" reactomeId="5682598" points="1399 1406, 1400 1381, 1399 1358" position="1400 1381" lineWidth="1.0"> <Inputs> <Input id="1548" points="1370 1409" /> <Input id="1464" points="1400 1436" /> </Inputs> <Outputs> <Output id="1550" points="1397 1321" /> <Output id="1551" points="1365 1350" /> </Outputs> <Catalysts> <Catalyst id="1464" points="1413 1436, 1437 1381" /> </Catalysts> <Properties> <displayName>ATM phosphorylates HERC2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1694" reactomeId="5682607" points="1396 1226, 1396 1207, 1396 1184" position="1396 1207" lineWidth="1.0"> <Inputs> <Input id="1550" points="1396 1252" /> <Input id="1695" points="1382 1227" /> </Inputs> <Outputs> <Output id="1696" points="1395 1155" /> <Output id="1697" 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<Properties> <displayName>RNF168 binds DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1879" reactomeId="5682858" points="1383 724, 1383 693, 1384 655" position="1383 693" lineWidth="1.0"> <Inputs> <Input id="1880" stoichiometry="12" points="1301 717" /> <Input id="1868" points="1387 753" /> </Inputs> <Outputs> <Output id="1881" /> </Outputs> <Catalysts> <Catalyst id="1868" points="1400 753, 1414 692" /> </Catalysts> <Properties> <displayName>RNF8 and RNF168 ubiquitinate H2AFX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2166" reactomeId="5682967" points="1756 1176, 1757 1192, 1757 1214" position="1757 1192" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2167" points="1715 1170" /> <Input id="1357" points="1757 1150" /> </Inputs> <Outputs> <Output id="2168" /> </Outputs> <Properties> <displayName>WHSC1 binds DNA DSBs</displayName> </Properties> 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<Outputs> <Output id="3035" /> </Outputs> <Properties> <displayName>Formation of BRCA1-A complex at DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3239" reactomeId="5683425" points="1076 1009, 1077 1044, 1076 1074" position="1077 1044" lineWidth="1.0"> <Inputs> <Input id="9430" points="1043 938" /> <Input id="9431" stoichiometry="2" points="1048 999" /> </Inputs> <Outputs> <Output id="3241" points="1054 1135" /> <Output id="3242" stoichiometry="2" points="1107 1094" /> </Outputs> <Catalysts> <Catalyst id="9430" points="1053 938, 1125 1042" /> </Catalysts> <Properties> <displayName>ATM phosphorylates TP53BP1 at DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3343" reactomeId="5683405" points="977 1078, 977 1035, 976 992" position="977 1035" lineWidth="1.0"> <Inputs> <Input id="3241" points="1013 1135" /> <Input id="3344" stoichiometry="2" points="946 1094" /> </Inputs> <Outputs> <Output id="9430" points="1005 938" /> <Output id="3345" stoichiometry="2" points="917 977" /> </Outputs> <Catalysts> <Catalyst id="3346" points="931 1035" /> </Catalysts> <Properties> <displayName>PPP5C dephosphorylates TP53BP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3802" reactomeId="5683735" points="616 1475, 616 1425" position="616 1425" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3400" points="577 1521" /> <Input id="1335" points="569 1473" /> </Inputs> <Outputs> <Output id="3803" /> </Outputs> <Properties> <displayName>CHEK2 is recruited to DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3845" reactomeId="5683774" points="712 1187, 723 1146, 733 1112" position="723 1146" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1338" stoichiometry="2" /> </Inputs> <Outputs> <Output id="3846" /> </Outputs> <Properties> <displayName>p-T68-CHEK2 dimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3857" reactomeId="5683792" points="643 1106, 616 1105, 583 1106" position="616 1105" lineWidth="1.0"> <Inputs> <Input id="3846" points="680 1099" /> <Input id="3858" stoichiometry="3" points="662 1133" /> </Inputs> <Outputs> <Output id="3859" stoichiometry="2" points="553 1099" /> <Output id="3860" stoichiometry="3" points="554 1137" /> </Outputs> <Catalysts> <Catalyst id="3846" points="680 1083, 615 1074" /> </Catalysts> <Properties> <displayName>p-T68-CHEK2 autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3875" reactomeId="5683801" points="372 1479, 380 1089, 379 1050" position="380 1089" lineWidth="1.0"> <Inputs> <Input id="3400" points="459 1521" /> <Input id="3876" points="331 1510" /> </Inputs> <Outputs> <Output id="3877" points="364 1007" /> <Output id="3878" points="509 1001" /> </Outputs> <Catalysts> <Catalyst id="3859" points="422 1088" /> </Catalysts> <Properties> <displayName>CHEK2 phosphorylates BRCA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3879" reactomeId="75172" points="237 580, 238 546, 238 510" position="238 546" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="79" points="213 602" /> <Input id="78" points="272 603" /> </Inputs> <Outputs> <Output id="80" /> </Outputs> <Properties> <displayName>Formation of RAD50:MRE11 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3880" reactomeId="75174" points="249 429, 268 428, 297 428" position="268 428" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="30" points="230 388" /> <Input id="80" points="241 468" /> </Inputs> <Outputs> <Output id="82" /> </Outputs> <Properties> <displayName>Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4051" reactomeId="5683930" points="1657 411, 1635 411, 1613 411" position="1635 411" lineWidth="1.0"> <Inputs> <Input id="4052" points="1679 400" /> <Input id="971" points="1703 428" /> </Inputs> <Outputs> <Output id="4038" points="1554 450" /> <Output id="4053" points="1592 400" /> </Outputs> <Catalysts> <Catalyst id="4054" points="1634 355" /> </Catalysts> <Properties> <displayName>WICH phosphorylates H2AFX on Y142</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4300" reactomeId="5683964" points="2001 671, 2002 693, 2001 721" position="2002 693" lineWidth="1.0"> <Inputs> <Input id="4301" points="1985 661" /> <Input id="4302" points="2024 659" /> </Inputs> <Outputs> <Output id="4303" points="2033 735" /> <Output id="4304" points="1979 740" /> </Outputs> <Catalysts> <Catalyst id="4130" points="1908 690" /> </Catalysts> <Properties> <displayName>ATM phosphorylates EYA1-4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4365" reactomeId="5683967" points="1758 739, 1757 760, 1758 791" position="1757 760" lineWidth="1.0"> <Inputs> <Input id="4366" points="1723 737" /> <Input id="4130" points="1758 712" /> </Inputs> <Outputs> <Output id="1015" points="1756 824" /> <Output id="4368" points="1718 792" /> </Outputs> <Catalysts> <Catalyst id="4304" points="1921 758" /> </Catalysts> <Properties> <displayName>EYA1-4 dephosphorylates tyrosine Y142 of H2AFX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4543" reactomeId="5683986" points="1984 578, 2026 578, 2038 524" position="2026 578" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4544" points="1972 562" /> <Input id="4130" points="1802 663" /> <Input id="4545" points="1946 579" /> </Inputs> <Outputs> <Output id="4546" /> </Outputs> <Properties> <displayName>APBB1 and MAPK8 bind diphosphorylated H2AFX</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4745" reactomeId="5684008" points="204 99, 224 99, 252 100" position="224 99" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4746" points="182 107" /> <Input id="4747" points="180 88" /> </Inputs> <Outputs> <Output id="4748" /> </Outputs> <Properties> <displayName>NBN binds KPNA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4785" reactomeId="5684006" points="293 116, 290 267, 291 308" position="290 267" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="4748" /> </Inputs> <Outputs> <Output id="4786" points="328 352" /> <Output id="30" points="238 356" /> </Outputs> <Properties> <displayName>KPNA2 translocates NBN to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9124" reactomeId="5686578" points="1427 295, 1425 313, 1427 335" position="1425 313" lineWidth="1.0"> <Inputs> <Input id="9125" points="1426 281" /> <Input id="9126" points="1448 294" /> </Inputs> <Outputs> <Output id="9128" points="1456 344" /> <Output id="9127" points="1403 348" /> </Outputs> <Catalysts> <Catalyst id="9432" points="1239 352" /> </Catalysts> <Properties> <displayName>Activated ATM phosphorylates ABL1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="9285" interactionType="Activate" points="528 487, 528 542" position="528 514" lineWidth="2.0"> <Inputs> <Input id="607" /> </Inputs> <Outputs> <Output id="9129" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="9288" reactomeId="5693612" points="558 422, 593 423, 621 422" position="593 423" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="607" points="535 459" /> <Input id="613" points="534 410" /> </Inputs> <Outputs> <Output id="611" /> </Outputs> <Properties> <displayName>MRN complex bound to DNA ends recruits ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9289" reactomeId="5693540" points="1094 434, 1124 434, 1150 432" position="1124 434" lineWidth="1.0"> <Inputs> <Input id="625" points="1058 429" /> <Input id="9290" stoichiometry="2" points="1075 480" /> </Inputs> <Outputs> <Output id="639" points="1223 424" /> <Output id="9432" points="1156 388" /> <Output id="9433" stoichiometry="2" points="1181 479" /> </Outputs> <Catalysts> <Catalyst id="625" points="1058 412, 1120 403" /> </Catalysts> <Properties> <displayName>MRN activates ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9307" reactomeId="5693598" points="1351 455, 1353 474, 1353 493" position="1353 474" lineWidth="1.0"> <Inputs> <Input id="639" points="1353 436" /> <Input id="9308" points="1314 454" /> </Inputs> <Outputs> <Output id="867" points="1355 516" /> <Output id="9309" points="1311 495" /> </Outputs> <Catalysts> <Catalyst id="639" points="1366 436, 1390 474" /> </Catalysts> <Properties> <displayName>ATM phosphorylates NBN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9325" reactomeId="5693602" points="1556 521, 1584 520, 1635 517" position="1584 520" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4038" points="1539 492" /> <Input id="867" points="1498 526" /> </Inputs> <Outputs> <Output id="9434" /> </Outputs> <Properties> <displayName>ATM recognizes H2AFX-Nucleosomes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9356" reactomeId="5693549" points="1745 513, 1742 606, 1743 574" position="1742 606" lineWidth="1.0"> <Inputs> <Input id="9435" points="1691 555" /> <Input id="9434" points="1638 513" /> </Inputs> <Outputs> <Output id="4130" points="1755 663" /> <Output id="9358" points="1697 616" /> </Outputs> <Catalysts> <Catalyst id="9434" points="1773 542, 1778 544" /> </Catalysts> <Properties> <displayName>ATM phosphorylates histone H2AFX on S139 at DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9374" reactomeId="5693583" points="1746 878, 1747 896, 1748 922" position="1747 896" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1015" points="1749 868" /> <Input id="1340" points="1715 880" /> </Inputs> <Outputs> <Output id="9436" /> </Outputs> <Properties> <displayName>MDC1 associates with gamma-H2AFX at nuclear foci</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9390" reactomeId="5693536" points="1750 1008, 1751 1033, 1751 1055" position="1751 1033" lineWidth="1.0"> <Inputs> <Input id="9437" stoichiometry="10" points="1718 994" /> <Input id="9436" points="1749 967" /> </Inputs> <Outputs> <Output id="9392" stoichiometry="10" points="1717 1066" /> <Output id="1357" points="1755 1102" /> </Outputs> <Catalysts> <Catalyst id="9436" points="1760 967, 1800 1030" /> </Catalysts> <Properties> <displayName>ATM phosphorylates MDC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9408" reactomeId="5693566" points="1022 806, 1022 825, 1023 850" position="1022 825" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2956" points="985 802" /> <Input id="2892" points="1021 785" /> </Inputs> <Outputs> <Output id="9430" /> </Outputs> <Properties> <displayName>TP53BP1 associates with H4K20Me2 at DNA DSBs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9409" reactomeId="5693551" points="802 1786, 726 1798, 571 1783" position="726 1798" lineWidth="1.0"> <Inputs> <Input id="3035" points="863 1778" /> <Input id="9410" stoichiometry="6" points="820 1814" /> </Inputs> <Outputs> <Output id="3400" points="549 1612" /> <Output id="9411" stoichiometry="6" points="521 1811" /> </Outputs> <Catalysts> <Catalyst id="3035" points="863 1754, 739 1753" /> </Catalysts> <Properties> <displayName>Phosphorylation of BRCA1-A complex at multiple sites by ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9470" reactomeId="5693609" points="1136 250, 1158 251, 1177 252" position="1158 251" lineWidth="1.0"> <Inputs> <Input id="9471" stoichiometry="4" points="1104 221" /> <Input id="8994" points="1112 251" /> </Inputs> <Outputs> <Output id="8997" points="1214 252" /> <Output id="9472" stoichiometry="4" points="1211 222" /> </Outputs> <Catalysts> <Catalyst id="9432" points="1158 348" /> </Catalysts> <Properties> <displayName>ATM phosphorylates TP53 at S15</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9711" reactomeId="3785704" points="568 317, 547 316, 504 317" position="547 316" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="9712" points="594 333" /> <Input id="9713" points="588 293" /> </Inputs> <Outputs> <Output id="96" /> </Outputs> <Properties> <displayName>DSB inducing agents induce double strand DNA breaks</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="9715" interactionType="Activate" points="632 908, 662 822" position="647 865" lineWidth="2.0"> <Inputs> <Input id="3878" /> </Inputs> <Outputs> <Output id="9714" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="9717" interactionType="Activate" points="543 908, 410 832" position="476 870" lineWidth="2.0"> <Inputs> <Input id="3878" /> </Inputs> <Outputs> <Output id="9716" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="9722" reactomeId="69891" points="659 1299, 680 1275, 704 1244" position="680 1275" lineWidth="1.0"> <Inputs> <Input id="3803" points="640 1329" /> <Input id="9428" points="712 1299" /> </Inputs> <Outputs> <Output id="3400" points="502 1521, 409 1429, 416 1239" /> <Output id="1338" points="708 1218" /> <Output id="9429" points="753 1249" /> </Outputs> <Catalysts> <Catalyst id="3803" points="622 1329, 632 1269" /> </Catalysts> <Properties> <displayName>Phosphorylation and activation of CHEK2 by ATM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9753" reactomeId="9701003" points="901 1588, 886 1548, 854 1522" position="886 1548" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="283" points="926 1675" /> <Input id="9754" points="878 1612" /> </Inputs> <Outputs> <Output id="9755" /> </Outputs> <Properties> <displayName>BAP1 binds BRCA1:BARD1 heterodimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9756" reactomeId="9700998" points="807 1522, 781 1536, 754 1563" position="781 1536" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="9755" /> </Inputs> <Outputs> <Output id="21" points="696 1666" /> <Output id="9723" points="780 1583" /> </Outputs> <Properties> <displayName>BAP1 disrupts the BRCA1:BARD1 heterodimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9788" reactomeId="9701000" points="961 1582, 967 1531, 961 1493" position="967 1531" lineWidth="1.0"> <Inputs> <Input id="9789" stoichiometry="6" points="988 1575" /> <Input id="283" points="933 1675" /> </Inputs> <Outputs> <Output id="9790" /> </Outputs> <Catalysts> <Catalyst id="283" points="930 1675, 935 1567" /> </Catalysts> <Inhibitors> <Inhibitor id="9723" points="829 1590" /> </Inhibitors> <Properties> <displayName>BRCA1:BARD1 heterodimer autoubiquitinates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9791" reactomeId="9707051" points="844 1448, 813 1452, 769 1460" position="813 1452" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9790" points="898 1459" /> <Input id="9792" points="833 1423" /> </Inputs> <Outputs> <Output id="9793" /> </Outputs> <Properties> <displayName>UBXN1 binds BRCA1:BARD1 heterodimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="9803" points="951 1675, 1010 1647" position="980 1661" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="283" /> </Inputs> <Outputs> <Output id="9802" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="9804" points="994 1493, 1076 1532, 1044 1603" position="1076 1532" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="9790" /> </Inputs> <Outputs> <Output id="9802" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="9805" reactomeId="5659781" points="789 1674, 831 1675, 877 1681" position="831 1675" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="21" points="728 1677" /> <Input id="9806" points="780 1704" /> </Inputs> <Outputs> <Output id="283" /> </Outputs> <Properties> <displayName>BRCA1 forms a heterodimer with BARD1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9820" reactomeId="9974238" points="506 1667, 407 1692, 317 1690" position="407 1692" lineWidth="1.0"> <Inputs> <Input id="21" points="654 1676" /> <Input id="9824" stoichiometry="3" points="523 1693" /> </Inputs> <Outputs> <Output id="9821" /> </Outputs> <Catalysts> <Catalyst id="9822" points="373 1655" /> </Catalysts> <Properties> <displayName>CRL4A-DCAF8L1 polyubiquitinates BRCA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9825" reactomeId="9974220" points="507 1756, 404 1726, 322 1732" position="404 1726" lineWidth="1.0"> <Inputs> <Input id="9806" points="751 1721" /> <Input id="9824" stoichiometry="3" points="523 1729" /> </Inputs> <Outputs> <Output id="9826" /> </Outputs> <Catalysts> <Catalyst id="9827" points="393 1773" /> </Catalysts> <Properties> <displayName>CRL4A-DCAF8L1,CRL4-DCAF8L2 polyubiquitinates BARD1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="9828" points="365 1655, 386 1773" position="375 1714" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="9822" /> </Inputs> <Outputs> <Output id="9827" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="9838" reactomeId="9974400" points="235 1604, 248 1563, 256 1471" position="248 1563" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="9839" /> </Inputs> <Catalysts> <Catalyst id="9842" points="215 1529" /> </Catalysts> <Properties> <displayName>26S Proteasome degrades polyubiquitinated BRCA1, BARD1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="9840" points="256 1674, 240 1654" position="248 1664" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="9821" /> </Inputs> <Outputs> <Output id="9839" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="9841" points="217 1734, 175 1733, 219 1654" position="175 1733" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="9826" /> </Inputs> <Outputs> <Output id="9839" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="9979" reactomeId="9988827" points="1557 218, 1557 242, 1557 258" position="1557 242" lineWidth="1.0"> <Inputs> <Input id="9980" points="1545 203" /> <Input id="9981" stoichiometry="3" points="1581 201" /> </Inputs> <Outputs> <Output id="9982" points="1593 262" /> <Output id="9983" stoichiometry="3" points="1557 293" /> </Outputs> <Catalysts> <Catalyst id="9432" points="1192 348, 1417 236" /> </Catalysts> <Properties> <displayName>Activated ATM phosphorylates PHF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9985" reactomeId="9988829" points="1725 261, 1746 262, 1775 262" position="1746 262" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9982" points="1693 263" /> <Input id="9986" points="1707 222" /> </Inputs> <Outputs> <Output id="9987" /> </Outputs> <Properties> <displayName>p-PHF6 binds SMARCA5</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of DNA Double Strand Break Response, Defective DNA double strand break response due to BRCA1 loss of function, and Defective DNA double strand break response due to BARD1 loss of function (512996)
