Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Resolution of Abasic Sites (AP sites)

Class:IdPathwayDiagram:512994
_displayNameDiagram of Resolution of Abasic Sites (AP sites)
_timestamp2018-11-22 15:36:02
created[InstanceEdit:512995] Matthews, L, 2010-02-16
height1610
modified[InstanceEdit:549332] Matthews, L, 2010-03-19
[InstanceEdit:622317] Matthews, L, 2010-04-22
[InstanceEdit:708313] Matthews, L, 2010-05-10
[InstanceEdit:3007689] Jassal, B, 2013-02-01
[InstanceEdit:5634880] Orlic-Milacic, Marija, 2014-11-06
[InstanceEdit:5637655] Orlic-Milacic, Marija, 2014-11-11
[InstanceEdit:5637667] Orlic-Milacic, Marija, 2014-11-12
[InstanceEdit:5644013] Orlic-Milacic, Marija, 2014-11-19
[InstanceEdit:5649480] Orlic-Milacic, Marija, 2014-11-20
[InstanceEdit:5649509] Orlic-Milacic, Marija, 2014-11-20
[InstanceEdit:5649551] Orlic-Milacic, Marija, 2014-11-20
[InstanceEdit:5649639] Orlic-Milacic, Marija, 2014-11-20
[InstanceEdit:5649719] Orlic-Milacic, Marija, 2014-11-20
[InstanceEdit:5649720] Orlic-Milacic, Marija, 2014-11-20
[InstanceEdit:5649736] Orlic-Milacic, Marija, 2014-11-21
[InstanceEdit:5649830] Orlic-Milacic, Marija, 2014-11-21
[InstanceEdit:5649852] Orlic-Milacic, Marija, 2014-11-21
[InstanceEdit:5649862] Orlic-Milacic, Marija, 2014-11-21
[InstanceEdit:5649863] Orlic-Milacic, Marija, 2014-11-21
[InstanceEdit:5649889] Orlic-Milacic, Marija, 2014-11-21
[InstanceEdit:5651663] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651716] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651728] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651757] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651785] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651796] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651797] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651806] Orlic-Milacic, Marija, 2014-11-24
[InstanceEdit:5651817] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651818] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651841] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651872] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651876] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651884] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651909] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5651929] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5658595] Orlic-Milacic, Marija, 2014-12-19
[InstanceEdit:5676979] Orlic-Milacic, Marija, 2015-02-20
[InstanceEdit:8866380] D'Eustachio, Peter, 2016-03-31
[InstanceEdit:8954146] Jassal, Bijay, 2017-01-05
[InstanceEdit:8954295] Jassal, Bijay, 2017-01-06
[InstanceEdit:8986535] Orlic-Milacic, Marija, 2017-04-28
[InstanceEdit:8986536] Orlic-Milacic, Marija, 2017-04-28
[InstanceEdit:8986542] Orlic-Milacic, Marija, 2017-04-28
[InstanceEdit:8986544] Orlic-Milacic, Marija, 2017-04-28
[InstanceEdit:8986545] Orlic-Milacic, Marija, 2017-04-28
[InstanceEdit:8986546] Orlic-Milacic, Marija, 2017-04-28
[InstanceEdit:9606673] Orlic-Milacic, Marija, 2018-04-24
[InstanceEdit:9616832] Orlic-Milacic, Marija, 2018-08-15
[InstanceEdit:9629649] Orlic-Milacic, Marija, 2018-11-22
representedPathway[Pathway:73933] Resolution of Abasic Sites (AP sites) [Homo sapiens]
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</Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2659" reactomeId="5651778" position="2756 990" bounds="2684 968 145 45" textPosition="2684 978" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>POLB:SSB(3'poly-dNMP)-dsDNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="2660" reactomeId="5651774" position="2579 1055" bounds="2533 1032 93 46" textPosition="2534 1037"> <Properties> <displayName>5'ddRP-FLAP-ssDNA</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="2662" reactomeId="54745" position="2575 1003" bounds="2554 992 42 22" textPosition="2556 992" /> <org.gk.render.RenderableProtein id="2744" reactomeId="53787" position="2692 1074" bounds="2669 1063 46 23" textPosition="2675 1064"> <Properties> <displayName>LIG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2745" reactomeId="5651769" position="2756 1133" bounds="2713 1102 86 63" textPosition="2719 1102" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIG1:POLB:SSB(3'poly-dNMP)-dsDNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2819" reactomeId="5651790" position="2755 1278" bounds="2715 1257 81 42" textPosition="2720 1264" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIG1:POLB:dsDNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2884" reactomeId="53845" position="2831 1318" bounds="2808 1304 46 28" textPosition="2812 1307" /> <org.gk.render.RenderableComplex id="3018" reactomeId="5651799" position="1429 1124" bounds="1380 1107 98 35" textPosition="1384 1107" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PCNA:POLD,POLE:RPA:RFC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3019" reactomeId="110407" position="1724 1126" bounds="1652 1094 144 65" textPosition="1652 1096" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3021" reactomeId="53845" position="1648 1064" bounds="1622 1049 53 31" textPosition="1630 1054"> <Properties> <displayName>POLB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="3063" reactomeId="5651812" position="2098 1113" bounds="2001 1086 194 54" textPosition="2004 1091" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3115" reactomeId="5651804" position="2538 1129" bounds="2458 1102 160 54" textPosition="2461 1107" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3198" reactomeId="5651808" position="2544 1255" bounds="2450 1227 188 56" textPosition="2452 1234" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="3250" reactomeId="5651810" position="2553 1384" bounds="2458 1366 191 37" textPosition="2461 1368" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="3273" reactomeId="50119" position="2699 1439" bounds="2663 1427 72 25" textPosition="2676 1429" /> <org.gk.render.RenderableChemical id="3427" reactomeId="113518" position="2264 751" bounds="2243 736 43 30" textPosition="2247 740" /> <org.gk.render.RenderableChemical id="3428" reactomeId="5651834" position="1784 742" bounds="1732 727 104 31" textPosition="1738 732"> <Properties> <displayName>ADP-D-ribose</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="3429" reactomeId="5651826" position="2002 839" bounds="1982 828 41 22" textPosition="1982 828"> <Properties> <displayName>PARG</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="3430" reactomeId="5634845" position="710 359" bounds="685 348 50 22" textPosition="685 348"> <Properties> <displayName>UNG-1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="3432" reactomeId="30555" position="1350 988" bounds="1328 975 45 27" textPosition="1330 978"> <Properties> <displayName>dNTP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntity id="3434" reactomeId="8952909" position="500 182" bounds="446 171 108 22" textPosition="446 171"> <Properties> <displayName>poly(ADP-ribose)</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableChemical id="3435" reactomeId="113521" position="470 118" bounds="449 103 43 30" textPosition="453 107" /> <org.gk.render.RenderableChemical id="3436" reactomeId="8952905" position="667 146" bounds="625 131 84 30" textPosition="629 135"> <Properties> <displayName>ADP-ribose</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="3437" reactomeId="8952910" position="543 105" bounds="511 94 64 22" textPosition="511 94"> <Properties> <displayName>ADPRHL2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="3438" reactomeId="5460" position="584 132" bounds="428 39 312 187" textPosition="562 60" bgColor="250 240 240" lineColor="255 153 102" insets="438 49 294 167"> <Properties> <displayName>mitochondrial matrix</displayName> </Properties> <Components> <Component id="3434" /> <Component id="3435" /> <Component id="3436" /> <Component id="3437" /> <Component id="3433" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="3441" reactomeId="70101" position="1515 807" bounds="79 12 2872 1590" textPosition="203 56" bgColor="250 240 240" lineColor="255 153 102" insets="87 20 2852 1572"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="1" /> <Component id="3438" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableEntitySet id="3458" reactomeId="9606670" position="826 809" bounds="801 798 51 22" textPosition="801 798"> <Properties> <displayName>MUTYH</displayName> </Properties> </org.gk.render.RenderableEntitySet> </Nodes> <Edges> <org.gk.render.RenderableReaction id="158" reactomeId="110349" points="560 405, 648 405, 681 392" position="648 405" lineWidth="1.0"> <Inputs> <Input id="159" points="380 655, 457 407" /> <Input id="62" points="543 388" /> </Inputs> <Outputs> <Output id="3430" points="700 373" /> <Output id="160" points="951 590, 862 451" /> </Outputs> <Properties> <displayName>Displacement of UNG glycosylase by APEX1 at the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="161" reactomeId="110350" points="579 469, 646 468, 677 468" position="646 468" lineWidth="1.0"> <Inputs> <Input id="159" points="383 655, 487 468" /> <Input id="70" points="567 453" /> </Inputs> <Outputs> <Output id="160" points="945 590, 801 469" /> <Output id="58" points="688 452" /> </Outputs> <Properties> <displayName>Displacement of TDG glycosylase by APEX1 at the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="162" reactomeId="110351" points="609 556, 662 556, 706 556" position="662 556" lineWidth="1.0"> <Inputs> <Input id="535" points="589 526" /> <Input id="159" points="391 655, 514 554" /> </Inputs> <Outputs> <Output id="81" points="720 533" /> <Output id="160" points="921 590, 798 553" /> </Outputs> <Properties> <displayName>Displacement of SMUG1 glycosylase by APEX1 at the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="164" reactomeId="110352" points="587 631, 669 637, 741 636" position="669 637" lineWidth="1.0"> <Inputs> <Input id="125" points="575 606" /> <Input id="159" points="416 663" /> </Inputs> <Outputs> <Output id="160" points="896 613" /> <Output id="106" points="753 601" /> </Outputs> <Properties> <displayName>Displacement of NTHL1 glycosylase by APEX1 at the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="110354" points="519 929, 648 932, 742 938" position="648 932" lineWidth="1.0"> <Inputs> <Input id="37" points="507 951" /> <Input id="159" points="378 686, 417 923" /> </Inputs> <Outputs> <Output id="160" points="956 620, 885 938" /> <Output id="19" points="762 962" /> </Outputs> <Properties> <displayName>Displacement of OGG1 glycosylase by APEX1 at the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="170" reactomeId="110355" points="545 776, 687 766, 801 765" position="687 766" lineWidth="1.0"> <Inputs> <Input id="159" points="388 686, 470 774" /> <Input id="31" points="531 798" /> </Inputs> <Outputs> <Output id="160" points="947 620" /> <Output id="3458" points="819 792" /> </Outputs> <Properties> <displayName>Displacement of MUTYH glycosylase by APEX1 at the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="172" reactomeId="110356" points="512 846, 652 848, 759 851" position="652 848" lineWidth="1.0"> <Inputs> <Input id="34" points="495 875" /> <Input id="159" points="381 686, 446 846" /> </Inputs> <Outputs> <Output id="4" points="790 885" /> <Output id="160" points="955 620, 881 844" /> </Outputs> <Properties> <displayName>Displacement of MPG glycosylase by APEX1 at the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="174" reactomeId="110359" points="1023 603, 1078 603, 1104 603" position="1078 603" lineWidth="1.0"> <Inputs> <Input id="160" /> </Inputs> <Outputs> <Output id="175" /> </Outputs> <Catalysts> <Catalyst id="160" points="987 590, 1046 568" /> </Catalysts> <Properties> <displayName>APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="176" reactomeId="110360" points="1349 614, 1349 614, 1413 535" position="1349 614" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="175" points="1322 612" /> <Input id="177" points="1367 665" /> </Inputs> <Outputs> <Output id="178" /> </Outputs> <Properties> <displayName>Recruitment of POLB to the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="179" reactomeId="110375" points="1538 501, 1588 498, 1616 500" position="1588 498" lineWidth="1.0"> <Inputs> <Input id="178" /> </Inputs> <Outputs> <Output id="180" points="1653 537" /> <Output id="181" points="1680 505" /> <Output id="2108" points="1659 450" /> </Outputs> <Catalysts> <Catalyst id="178" points="1451 501, 1544 456" /> </Catalysts> <Properties> <displayName>Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="182" reactomeId="110376" points="1885 516, 1906 515, 1990 516" position="1906 515" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="181" points="1842 514" /> <Input id="183" points="1904 462" /> </Inputs> <Outputs> <Output id="184" /> </Outputs> <Properties> <displayName>Recruitment of LIG3:XRCC1 complex to the site of repair by POLB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="195" reactomeId="73931" points="2381 512, 2425 511, 2465 511" position="2425 511" lineWidth="1.0"> <Inputs> <Input id="194" /> </Inputs> <Outputs> <Output id="196" /> </Outputs> <Catalysts> <Catalyst id="194" points="2350 493, 2404 463" /> </Catalysts> <Properties> <displayName>LIG3-mediated DNA ligation via the single-nucleotide replacement pathway</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="198" reactomeId="110380" points="2599 512, 2632 512, 2653 511" position="2632 512" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="196" /> </Inputs> <Outputs> <Output id="854" points="2696 511" /> <Output id="2110" points="2737 456" /> <Output id="2114" points="2654 539" /> </Outputs> <Properties> <displayName>Dissociation of LIG3:XRCC1 complex from the BER site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="241" reactomeId="110353" points="608 703, 682 700, 741 702" position="682 700" lineWidth="1.0"> <Inputs> <Input id="100" points="595 717" /> <Input id="159" points="416 675" /> </Inputs> <Outputs> <Output id="239" points="765 717" /> <Output id="160" points="932 620" /> </Outputs> <Properties> <displayName>Displacement of MBD4 glycosylase by APEX1 at the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="626" interactionType="Activate" points="308 672, 338 671" position="323 671" lineWidth="2.0"> <Inputs> <Input id="463" /> </Inputs> <Outputs> <Output id="159" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="797" reactomeId="73932" points="2155 521, 2177 522, 2212 521" position="2177 522" lineWidth="1.0"> <Inputs> <Input id="184" points="2121 519" /> <Input id="798" points="2168 538" /> </Inputs> <Outputs> <Output id="194" points="2257 518" /> <Output id="803" points="2237 541" /> </Outputs> <Catalysts> <Catalyst id="184" points="2107 495, 2150 482" /> </Catalysts> <Properties> <displayName>Resynthesis of excised residue by POLB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="865" reactomeId="5649701" points="584 1001, 643 999, 685 1000" position="643 999" lineWidth="1.0"> <Inputs> <Input id="866" points="547 1028" /> <Input id="37" points="533 984" /> </Inputs> <Outputs> <Output id="19" points="736 984" /> <Output id="867" points="727 1027" /> </Outputs> <Properties> <displayName>NEIL1,NEIL2 displace OGG1 from AP-dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="898" reactomeId="5649711" points="805 1049, 865 1050, 987 994" position="865 1050" lineWidth="1.0"> <Inputs> <Input id="867" /> </Inputs> <Outputs> <Output id="899" /> </Outputs> <Catalysts> <Catalyst id="867" points="805 1036, 832 1029" /> </Catalysts> <Properties> <displayName>NEIL1,NEIL2 incises DNA strand 5' to the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="940" reactomeId="5649708" points="1456 771, 1455 772, 1454 639" position="1455 772" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="177" points="1387 702" /> <Input id="899" points="1042 962" /> </Inputs> <Outputs> <Output id="942" /> </Outputs> <Properties> <displayName>NEIL1,NEIL2 recruits POLB to incised AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="973" reactomeId="5649705" points="2000 609, 2022 608, 2044 608" position="2022 608" lineWidth="1.0"> <Inputs> <Input id="1072" points="1977 611" /> <Input id="1784" points="1994 638" /> </Inputs> <Outputs> <Output id="1782" points="2073 610" /> <Output id="976" points="2056 642" /> </Outputs> <Catalysts> <Catalyst id="1072" points="1961 590, 2002 573" /> </Catalysts> <Properties> <displayName>PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1071" reactomeId="5649726" points="1804 609, 1790 608, 1839 612" position="1790 608" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="183" points="1901 462" /> <Input id="1040" points="1764 611" /> <Input id="941" points="1793 635" /> </Inputs> <Outputs> <Output id="1072" /> </Outputs> <Properties> <displayName>LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1135" reactomeId="5649723" points="2215 611, 2232 612, 2267 610" position="2232 612" lineWidth="1.0"> <Inputs> <Input id="798" points="2186 571" /> <Input id="1782" points="2197 612" /> </Inputs> <Outputs> <Output id="1136" points="2299 611" /> <Output id="803" points="2255 573" /> </Outputs> <Catalysts> <Catalyst id="1782" points="2193 643, 2210 647" /> </Catalysts> <Properties> <displayName>POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1157" reactomeId="5649734" points="2424 615, 2471 616, 2500 615" position="2471 616" lineWidth="1.0"> <Inputs> <Input id="1136" /> </Inputs> <Outputs> <Output id="1158" /> </Outputs> <Catalysts> <Catalyst id="1136" points="2424 597, 2447 590" /> </Catalysts> <Properties> <displayName>LIG3 ligates NEIL1,NEIL2-generated single strand break</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1179" reactomeId="5649724" points="2632 621, 2663 625, 2697 629" position="2663 625" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="1158" /> </Inputs> <Outputs> <Output id="854" points="2727 528" /> <Output id="2110" points="2776 456, 2795 541" /> <Output id="2112" points="2736 654" /> <Output id="2114" points="2664 576" /> <Output id="2126" points="2685 683" /> </Outputs> <Properties> <displayName>LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1678" reactomeId="5649725" points="1517 613, 1565 615, 1586 615" position="1565 615" lineWidth="1.0"> <Inputs> <Input id="942" /> </Inputs> <Outputs> <Output id="180" points="1646 574" /> <Output id="1040" points="1639 615" /> </Outputs> <Catalysts> <Catalyst id="942" points="1517 589, 1543 579" /> </Catalysts> <Properties> <displayName>POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1985" reactomeId="5649856" points="1212 621, 1212 655, 1214 693" position="1212 655" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="175" /> </Inputs> <Outputs> <Output id="1986" /> </Outputs> <Properties> <displayName>Oxidative damage to the AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1987" reactomeId="5649854" points="1296 783, 1296 805, 1296 915" position="1296 805" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="177" points="1361 702" /> <Input id="1986" points="1248 749" /> </Inputs> <Outputs> <Output id="1988" /> </Outputs> <Properties> <displayName>Recruitment of POLB to oxidatively damaged AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2042" reactomeId="111253" points="1372 941, 1404 941, 1430 940" position="1404 941" lineWidth="1.0"> <Inputs> <Input id="1988" points="1341 941" /> <Input id="3432" points="1356 972" /> </Inputs> <Outputs> <Output id="2044" points="1477 940" /> <Output id="2046" points="1443 971" /> </Outputs> <Catalysts> <Catalyst id="1988" points="1341 919, 1370 901" /> </Catalysts> <Properties> <displayName>POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2137" reactomeId="5649873" points="1657 942, 1687 943, 1712 944" position="1687 943" lineWidth="1.0"> <Inputs> <Input id="2138" points="1660 862" /> <Input id="2044" points="1618 941" /> <Input id="2139" points="1622 998" /> </Inputs> <Outputs> <Output id="2140" points="1773 945" /> <Output id="2142" points="1760 877" /> </Outputs> <Activators> <Activator id="3429" points="1979 838, 1721 836" /> </Activators> <Properties> <displayName>PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2213" reactomeId="5649883" points="1930 942, 1953 942, 1983 942" position="1953 942" lineWidth="1.0"> <Inputs> <Input id="2140" points="1903 943" /> <Input id="2216" stoichiometry="10" points="1914 992" /> </Inputs> <Outputs> <Output id="2214" points="2016 942" /> <Output id="2228" stoichiometry="10" points="1997 992" /> </Outputs> <Catalysts> <Catalyst id="2140" points="1878 910, 1902 894" /> </Catalysts> <Properties> <displayName>POLB-mediated DNA strand displacement synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2447" reactomeId="5651723" points="2219 939, 2243 939, 2265 941" position="2243 939" lineWidth="1.0"> <Inputs> <Input id="2448" points="2208 987" /> <Input id="2214" points="2197 940" /> </Inputs> <Outputs> <Output id="2449" points="2278 985" /> <Output id="2450" points="2322 939" /> </Outputs> <Catalysts> <Catalyst id="2214" points="2179 910, 2218 896" /> </Catalysts> <Properties> <displayName>PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2533" reactomeId="5651739" points="2433 934, 2458 932, 2473 931" position="2458 932" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="2450" /> </Inputs> <Outputs> <Output id="2534" points="2480 875" /> <Output id="2535" points="2502 931" /> </Outputs> <Properties> <displayName>PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2658" reactomeId="5651782" points="2613 934, 2667 937, 2700 938" position="2667 937" lineWidth="1.0"> <Inputs> <Input id="2535" /> </Inputs> <Outputs> <Output id="2659" points="2731 965" /> <Output id="2660" points="2602 1029" /> <Output id="2662" points="2599 992" /> </Outputs> <Catalysts> <Catalyst id="2535" points="2613 916, 2640 907" /> </Catalysts> <Properties> <displayName>FEN1 bound to POLB cleaves displaced DNA strand (flap)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2743" reactomeId="5651773" points="2750 1041, 2751 1062, 2753 1099" position="2751 1062" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2659" points="2753 1016" /> <Input id="2744" points="2712 1060" /> </Inputs> <Outputs> <Output id="2745" /> </Outputs> <Properties> <displayName>LIG1 binds POLB at long-patch BER site</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2818" reactomeId="5651789" points="2754 1168, 2752 1213, 2754 1254" position="2752 1213" lineWidth="1.0"> <Inputs> <Input id="2745" /> </Inputs> <Outputs> <Output id="2819" /> </Outputs> <Catalysts> <Catalyst id="2745" points="2737 1168, 2721 1193" /> </Catalysts> <Properties> <displayName>LIG1 bound to POLB ligates SSB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2882" reactomeId="5651792" points="2784 1254, 2812 1237, 2842 1257" position="2812 1237" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="2819" /> </Inputs> <Outputs> <Output id="854" points="2738 528, 2844 762" /> <Output id="2744" points="2692 1089, 2697 1318, 2783 1317" /> <Output id="2884" points="2833 1301" /> </Outputs> <Properties> <displayName>LIG1 and POLB dissociate from repaired dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3017" reactomeId="110364" points="1550 1123, 1583 1123, 1612 1122" position="1583 1123" lineWidth="1.0"> <Inputs> <Input id="3018" points="1481 1123" /> <Input id="2139" points="1609 1026" /> <Input id="2044" points="1547 970" /> </Inputs> <Outputs> <Output id="3019" points="1649 1123" /> <Output id="3021" points="1638 1083" /> </Outputs> <Properties> <displayName>PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3062" reactomeId="110368" points="1858 1122, 1912 1119, 1949 1118" position="1912 1119" lineWidth="1.0"> <Inputs> <Input id="3019" points="1799 1123" /> <Input id="2216" stoichiometry="10" points="1904 1025" /> </Inputs> <Outputs> <Output id="3063" points="1998 1116" /> <Output id="2228" stoichiometry="10" points="1994 1024" /> </Outputs> <Catalysts> <Catalyst id="3019" points="1799 1146, 1842 1159" /> </Catalysts> <Properties> <displayName>POLD,POLE-mediated DNA strand displacement synthesis</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3114" reactomeId="110363" points="2198 1114, 2257 1115, 2311 1115" position="2257 1115" lineWidth="1.0"> <Inputs> <Input id="3063" /> </Inputs> <Outputs> <Output id="3115" points="2455 1124" /> <Output id="2660" points="2530 1065" /> <Output id="2662" points="2551 1011" /> </Outputs> <Catalysts> <Catalyst id="3063" points="2188 1083, 2222 1076" /> </Catalysts> <Properties> <displayName>FEN1 bound to PCNA and APEX1 cleaves flap ssDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3166" reactomeId="110371" points="2539 1195, 2540 1195, 2542 1224" position="2540 1195" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3115" points="2538 1159" /> <Input id="2744" points="2682 1089, 2596 1193" /> </Inputs> <Outputs> <Output id="3198" /> </Outputs> <Properties> <displayName>LIG1 binds APEX1 and PCNA at SSB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3249" reactomeId="5651805" points="2545 1286, 2549 1330, 2551 1363" position="2549 1330" lineWidth="1.0"> <Inputs> <Input id="3198" /> </Inputs> <Outputs> <Output id="3250" /> </Outputs> <Catalysts> <Catalyst id="3198" points="2515 1286, 2492 1306" /> </Catalysts> <Properties> <displayName>LIG1 bound to APEX1 and PCNA ligates SSB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3271" reactomeId="5651809" points="2583 1363, 2641 1330, 2676 1345" position="2641 1330" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="3250" /> </Inputs> <Outputs> <Output id="3018" points="1458 1145, 1875 1387, 2653 1439" /> <Output id="2744" points="2691 1089" /> <Output id="3273" points="2695 1424" /> <Output id="854" points="2740 528, 2861 729, 2863 1065, 2865 1357, 2695 1359" /> </Outputs> <Properties> <displayName>LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3426" reactomeId="5651828" points="2195 788, 2002 787, 1850 788" position="2002 787" lineWidth="1.0"> <Inputs> <Input id="3427" points="2240 762" /> <Input id="2534" points="2441 837" /> </Inputs> <Outputs> <Output id="3428" points="1806 761" /> <Output id="2138" points="1692 828" /> </Outputs> <Catalysts> <Catalyst id="3429" points="2002 825" /> </Catalysts> <Properties> <displayName>PARG dePARylates PARP1,PARP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3433" reactomeId="8952903" points="516 146, 544 146, 588 146" position="544 146" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="3434" points="504 168" /> <Input id="3435" points="495 131" /> </Inputs> <Outputs> <Output id="3436" points="622 146" /> <Output id="3434" points="526 168" /> </Outputs> <Catalysts> <Catalyst id="3437" points="543 119" /> </Catalysts> <Properties> <displayName>ADPRHL2 hydrolyses poly(ADP-ribose)</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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