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Details on Person UniProt:P63100-1 Ppp3r1
| Class:Id | ReferenceIsoform:51296 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-170 added on Fri February 6 2015;initiator methionine:1 for 51296 removed on Fri Nov 03 2023;initiator methionine: for 51296 added on Fri Nov 03 2023;initiator methionine: for 51296 removed on Fri Aug 15 2025;initiator methionine:1 for 51296 added on Fri Aug 15 2025 |
| _displayName | UniProt:P63100-1 Ppp3r1 |
| _timestamp | 2025-08-15 21:13:22 |
| chain | initiator methionine:1 chain:2-170 |
| checksum | C904715DC0386056 |
| comment | FUNCTION Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.SUBUNIT Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:24018048). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). The regulatory subunit confers calcium sensitivity. Interacts with catalytic subunit PPP3CA/calcineurin A (PubMed:24018048). Interacts with catalytic subunit PPP3CB/calcineurin A (By similarity). Interacts with CIB1 (via C-terminal region); the interaction increases upon cardiomyocyte hypertrophy. Interacts with RCAN1 (By similarity). Interacts with SPATA33 (via PQIIIT motif) (By similarity).SUBCELLULAR LOCATION Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy.ALTERNATIVE PRODUCTS Isoform 2 is testis specific.MISCELLANEOUS This protein has four functional calcium-binding sites.SIMILARITY Belongs to the calcineurin regulatory subunit family. |
| description | recommendedName: Calcineurin subunit B type 1 alternativeName: Protein phosphatase 2B regulatory subunit 1 alternativeName: Protein phosphatase 3 regulatory subunit B alpha isoform 1 |
| geneName | Ppp3r1 Cna2 Cnb |
| identifier | P63100 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Calcium Cell membrane Cytoplasm Lipoprotein Membrane Metal-binding Myristate Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618410] Weiser, JD [InstanceEdit:5618413] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Ppp3r1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CANB1_RAT P06705 P15117 Q08044 |
| sequenceLength | 170 |
| species | [Species:48895] Rattus norvegicus |
| variantIdentifier | P63100-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P63100-1 Ppp3r1 (51296)
