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Details on Person UniProt:P63098 PPP3R1
| Class:Id | ReferenceGeneProduct:51292 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-170 added on Fri February 6 2015;initiator methionine:1 for 51292 removed on Fri Nov 03 2023;initiator methionine: for 51292 added on Fri Nov 03 2023;initiator methionine: for 51292 removed on Fri Aug 15 2025;initiator methionine:1 for 51292 added on Fri Aug 15 2025 |
| _displayName | UniProt:P63098 PPP3R1 |
| _timestamp | 2025-08-15 21:13:21 |
| chain | initiator methionine:1 chain:2-170 |
| checksum | C904715DC0386056 |
| comment | FUNCTION Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.SUBUNIT Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit (also known as calcineurin B) (PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:26794871, PubMed:27974827, PubMed:8524402). There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). Interacts with catalytic subunit PPP3CA/calcineurin A (PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:27974827, PubMed:31375679, PubMed:8524402). Interacts with catalytic subunit PPP3CB/calcineurin A (PubMed:26794871). Interacts with CIB1 (via C-terminal region); the interaction increases upon cardiomyocyte hypertrophy (By similarity). Interacts with RCAN1 (PubMed:12809556). Interacts with SPATA33 (via PQIIIT motif) (PubMed:34446558).INTERACTION Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy.MISCELLANEOUS This protein has four functional calcium-binding sites (PubMed:12218175, PubMed:12357034, PubMed:17498738, PubMed:22343722, PubMed:23468591, PubMed:26794871, PubMed:27974827, PubMed:8524402). Although African swine fever virus infects pigs and not humans, human PPP3R1 and PPP3CA have been used for the crystallization. PPP3CA and PPP3R1 interact with African swine fever virus Mal-047/A238L (via PKIIIT and FLCVK motifs); the interaction does not block catalytic activity per se but inhibits PPP3CA function by blocking the access to the two substrate recognition (PubMed:23468591).SIMILARITY Belongs to the calcineurin regulatory subunit family. |
| description | recommendedName: Calcineurin subunit B type 1 alternativeName: Protein phosphatase 2B regulatory subunit 1 alternativeName: Protein phosphatase 3 regulatory subunit B alpha isoform 1 |
| geneName | PPP3R1 CNA2 CNB |
| identifier | P63098 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cell membrane Cytoplasm Direct protein sequencing Lipoprotein Membrane Metal-binding Myristate Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PPP3R1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997605] ENSEMBL:ENSG00000221823 PPP3R1 [Homo sapiens] |
| secondaryIdentifier | CANB1_HUMAN B2RC10 B5MDU4 P06705 P15117 Q08044 Q53SL0 |
| sequenceLength | 170 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:51291] PPP3R1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2685631] PPP3R1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P63098 PPP3R1 (51292)
