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Details on Person UniProt:P55291 CDH15
| Class:Id | ReferenceGeneProduct:51236 |
|---|---|
| _chainChangeLog | signal peptide:1-21 added on Fri February 6 2015;propeptide:22-60 added on Fri February 6 2015;chain:61-814 added on Fri February 6 2015 |
| _displayName | UniProt:P55291 CDH15 |
| _timestamp | 2024-11-03 20:18:11 |
| chain | signal peptide:1-21 propeptide:22-60 chain:61-814 |
| checksum | 618A817DBF2B3343 |
| comment | FUNCTION Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.INTERACTION Expressed in the brain and cerebellum.DOMAIN Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.DISEASE A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe intellectual disability and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Cadherin-15 alternativeName: Cadherin-14 alternativeName: Muscle cadherin shortName: M-cadherin |
| geneName | CDH15 CDH14 CDH3 |
| identifier | P55291 |
| isSequenceChanged | FALSE |
| keyword | Calcium Cell adhesion Cell membrane Chromosomal rearrangement Cleavage on pair of basic residues Disease variant Glycoprotein Intellectual disability Membrane Metal-binding Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CDH15 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001044] ENSEMBL:ENSG00000129910 CDH15 [Homo sapiens] |
| secondaryIdentifier | CAD15_HUMAN |
| sequenceLength | 814 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:375055] CDH15 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P55291 CDH15 (51236)
