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Details on Person UniProt:P43155 CRAT
| Class:Id | ReferenceGeneProduct:51208 |
|---|---|
| _chainChangeLog | chain:1-626 added on Fri February 6 2015 |
| _displayName | UniProt:P43155 CRAT |
| _timestamp | 2025-02-21 19:16:02 |
| chain | chain:1-626 |
| checksum | 51B65E7C94E458D7 |
| comment | FUNCTION Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed:15099582, PubMed:29395073). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed:23485643). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed:23485643). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643).CATALYTIC ACTIVITY (R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoACATALYTIC ACTIVITY propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY hexanoyl-CoA + (R)-carnitine = O-hexanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY 3-methylbutanoyl-CoA + (R)-carnitine = O-3-methylbutanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY 2-methylpropanoyl-CoA + (R)-carnitine = O-isobutanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY 2-methylbutanoyl-CoA + (R)-carnitine = O-2-methylbutanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY acetoacetyl-CoA + (R)-carnitine = O-3-oxobutanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY 3-hydroxybutanoyl-CoA + (R)-carnitine = O-3-hydroxybutanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY 4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoACATALYTIC ACTIVITY 2,6-dimethylheptanoyl-CoA + (R)-carnitine = O-2,6-dimethylheptanoyl-(R)-carnitine + CoABIOPHYSICOCHEMICAL PROPERTIES Monomer.SUBCELLULAR LOCATION Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the carnitine/choline acetyltransferase family. |
| description | recommendedName: fullName evidence="13"Carnitine O-acetyltransferase shortName: Carnitine acetylase ecNumber evidence="6"2.3.1.137 ecNumber evidence="4 6"2.3.1.7 alternativeName: Carnitine acetyltransferase shortName: CAT shortName evidence="11"CrAT |
| geneName | CRAT CAT1 |
| identifier | P43155 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Acyltransferase Alternative splicing Direct protein sequencing Endoplasmic reticulum Fatty acid metabolism Lipid metabolism Membrane Mitochondrion Mitochondrion inner membrane Neurodegeneration Peroxisome Proteomics identification Reference proteome Transferase Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CRAT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992336] ENSEMBL:ENSG00000095321 CRAT [Homo sapiens] |
| secondaryIdentifier | CACP_HUMAN Q5T952 Q9BW16 |
| sequenceLength | 626 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144890] UniProt:P43155-2 CRAT [Homo sapiens] [ReferenceIsoform:221135] UniProt:P43155-3 CRAT [Homo sapiens] [ReferenceIsoform:404052] UniProt:P43155-1 CRAT [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:390293] CRAT [peroxisomal matrix] [Homo sapiens] [EntityWithAccessionedSequence:9033096] CRAT [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9971122] CRAT [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P43155 CRAT (51208)
